My research group aims to gain a detailed understanding of how regulation is achieved distinct levels of organization in cellular systems. We place a particular emphasis on understanding how the precise structure and intrinsically disordered regions of proteins contribute to cellular regulation. Specifically, we investigate regulation at three levels of organization: molecules, processes and genomes. At the molecular level, we aim to discover novel features of regulatory and signalling proteins. At the process level, we aim to understand how the different regulatory mechanisms contribute to cellular homeostasis. At the genome level, we study the interplay between regulation and genome evolution.
The ultimate goal of our research programme is to decipher the molecular basis of human diseases caused by regulatory dysfunction. To this end, we develop new genome-scale experimental approaches and computational methods to mine and integrate disparate datasets from diverse model organisms. We envision that the findings from our research will help to better understand how mutations that affect various regulatory processes result in dysfunctions associated with diseases, and that the discovery of design principles of regulation can be exploited in biotechnology and medicine.
- Sanchez de Groot, N., Torrent Burgas, M., Ravarani, C.N., Trusina, A., Ventura, S., Babu, M.M. (2019)
The Fitness Cost and Benefit of Phase-Separated Protein Deposits
Mol. Syst. Biol. 15: e8075.
- Hauser, A.S., Chavali, S., Masuho, I., Jahn L.J., Martemyanov, K.A., Gloriam, D.E., Babu, M.M. (2018)
Pharmacogenomics of GPCR Drug Targets
Cell 172: 41-54.
- Kayikci, M., Venkatakrishnan, A.J., Scott-Brown, J., Ravarani, C.N., Flock, T., Babu, M.M. (2018)
Visualization and Analysis of Non-Covalent Contacts Using the Protein Contacts Atlas
Nat. Struct. Mol. Biol. 25: 185-194.
- Ravarani, C.N., Erkina, T.Y., De Baets, G., Dudman, D.C., Erkine, A.M., Babu, M.M. (2018)
High-throughput Discovery of Functional Disordered Regions: Investigation of Transactivation Domains
Mol. Syst. Biol. 14: e8075.
- Torrent, M., Chalancon, G., Sanchez de Groot, N., Wuster, A., Babu, M.M. (2018)
Cells Alter Their tRNA Abundance to Selectively Regulate Protein Synthesis During Stress Conditions
Sci. Signal 11: eaat6409.
- Flock, T., Hauser, A.S., Lund, N., Gloriam, D.E., Balaji, S., Babu, M.M. (2017)
Selectivity Determinants of GPCR-G-protein Binding
Nature 545: 317-322.
- Venkatakrishnan, A.J., Deupi, X., Lebon, G., Heydenreich, F.M., Flock, T., Miljus, T., Balaji, S., Bouvier, M., Veprintsev, D.B., Tate, C.G., Schertler, G.F.X., Babu, M.M. (2016)
Diverse Activation Pathways in Class A GPCRs Converge Near the G-protein-coupling Region
Nature 536: 484-7.
- Latysheva, N.S., Oates, M.E., Maddox, M., Flock, T., Gough, J., Buljan, M., Weatheritt, R.J., Babu, M.M. (2016)
Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer
Mol. Cell 63: 579-592.
- Flock, T., Ravarani, C.N., Sun, D., Venkatakrishnan, A.J., Kayikci, M., Tate, C.G., Veprintsev, D.B. and Babu, M.M. (2015)
Universal allosteric mechanism for Gα activation by GPCRs.
Nature 524: (7564):173-179.
- Venkatakrishnan, A.J., Deupi, X., Lebon, G., Tate, C.G., Schertler, G.F. and Babu, M.M. (2013)
Molecular signatures of G-protein-coupled receptors.
Nature 494: (7436):185-194.
- Hannes Harbrecht