My research group aims to gain a detailed understanding of how regulation is achieved distinct levels of organization in cellular systems. We place a particular emphasis on understanding how the precise structure and intrinsically disordered regions of proteins contribute to cellular regulation. Specifically, we investigate regulation at three levels of organization: molecules, processes and genomes. At the molecular level, we aim to discover novel features of regulatory and signalling proteins. At the process level, we aim to understand how the different regulatory mechanisms contribute to cellular homeostasis. At the genome level, we study the interplay between regulation and genome evolution.
The ultimate goal of our research programme is to decipher the molecular basis of human diseases caused by regulatory dysfunction. To this end, we develop new genome-scale experimental approaches and computational methods to mine and integrate disparate datasets from diverse model organisms. We envision that the findings from our research will help to better understand how mutations that affect various regulatory processes result in dysfunctions associated with diseases, and that the discovery of design principles of regulation can be exploited in biotechnology and medicine.
- Flock, T., Ravarani, C.N., Sun, D., Venkatakrishnan, A.J., Kayikci, M., Tate, C.G., Veprintsev, D.B. and Babu, M.M. (2015)
Universal allosteric mechanism for Gα activation by GPCRs.
Nature 524: (7564):173-179.
- Weatheritt, R.J., Gibson, T.J. and Babu, M.M. (2014)
Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems.
Nat Struct Mol Biol. 21: (9):833-839.
- van der Lee, R., Lang, B., Kruse, K., Gsponer, J., Sánchez de Groot, N., Huynen, M.A., Matouschek, A., Fuxreiter, M. and Babu, M.M. (2014)
Intrinsically disordered segments affect protein half-life in the cell and during evolution.
Cell Rep. 8: (6):1832-1844.
- van der Lee, R., Buljan, M., Lang, B., Weatheritt, R.J., Daughdrill, G.W., Dunker, A.K., Fuxreiter, M., Gough, J., Gsponer, J., Jones, D.T., Kim, P.M., Kriwacki, R.W., Oldfield, C.J., Pappu, R.V., Tompa, P., Uversky, V.N., Wright, P.E. and Babu, M.M. (2014)
Classification of intrinsically disordered regions and proteins.
Chem Rev. 114: (13):6589-6631.
- Tompa, P., Davey, N.E., Gibson, T.J. and Babu, M.M. (2014)
A million peptide motifs for the molecular biologist.
Mol Cell. 55: (2):161-169.
- Venkatakrishnan, A.J., Deupi, X., Lebon, G., Tate, C.G., Schertler, G.F. and Babu, M.M. (2013)
Molecular signatures of G-protein-coupled receptors.
Nature 494: (7436):185-194.
- Buljan, M., Chalancon, G., Eustermann, S., Wagner, G.P., Fuxreiter, M., Bateman, A. and Babu, M.M. (2012)
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks.
Mol Cell. 46: (6):871-883.
- Babu, M.M., Kriwacki, R. and Pappu, R.V. (2012)
Versatility from protein disorder.
Science 337: (6101):1460-1461.