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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Image365

LMB 365 – Day 257

Published on 14 September, 2019

This photo for day 257 of #LMB365 was taken from Hobson’s Park, south-west of the LMB, which is part of the Great Kneighton development.

LMB 365 – Day 256

Published on 13 September, 2019

KDEL is the sorting signal for luminal ER proteins. In this a classic experiment for day 256 of #LMB365, lysozyme was expressed in COS cells without (left) or with (right) the addition of the sequence SEKDEL, and detected by immunofluorescence. Normally, lysozyme is rapidly secreted and the main pool of intracellular protein is in transit through the Golgi apparatus. Addition of KDEL causes it to accumulate to high levels in the ER. This was the original proof that (SE)KDEL is a sufficient signal for ER retention.

LMB 365 – Day 255

Published on 12 September, 2019

This image for day 255 of #LMB365 shows our Head of Scientific Computing donating the LMB’s old line printer to the Centre for Computing History (CCH) in Cambridge http://www.computinghistory.org.uk/. The printer was bought in 1991 for £8,125 and has been in constant use until very recently… Before graphics terminals became so sophisticated and image processing so automated, the LMB’s line printer gave essential output of large scale images and transforms for manual analysis of helical assemblies, such as tubes of the acetylcholine receptor

LMB 365 – Day 254

Published on 11 September, 2019

Day 254 of #LMB365 showsa reflection of the LMB in the nearby AstraZeneca building at sunset. We wonder whether they can see similar reflections of their building in the glass façade of our building?

LMB 365 – Day 253

Published on 10 September, 2019

As the model organismC. elegansis transparent we can use it to look at subcellular organelles and use fluorescent protein tags to study different processes. This image for day 253 of #LMB365 shows two different organelles labelled with green and magenta, which shows as white if there is co-localisation

LMB 365 – Day 252

Published on 9 September, 2019

Day 252 of #LMB365 shows the LMB’s Research Office who had an awesome team day recently and visited the LMB’s animal facility. They learned more about the work carried out there and how the mice are cared for.

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