This image for day 160 of #LMB365 is a Drosophila melanogaster embryo showing the embryonic nervous system. Fluorescent labels correspond to microtubules (yellow) and nuclei (red). Image by Yara Sanchez-Corrales in Katja Röper’s group in the Cell Biology Division.
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LMB 365 – Day 159
Day 159 of #LMB365 shows Francis Crick in the 1960s, when he was joint head of the LMB’s Molecular Genetics (now Cell Biology) Division. Francis was born on this day in 1916, in Northampton. He was awarded the 1962 Nobel Prize for Physiology or Medicine for the discovery of the structure of DNA
LMB 365 – Day 158
Between the floors of the LMB’s building are full height Interstitial Service Voids (ISVs), which house the ductwork, pipes and services. These ISVs are normally only accessible for maintenance and modifications by the Estates and Facilities team. The team recently ran some “Secret LMB Tours” for the LMB’s students to allow them to see behind the scenes in these areas and this photo for day 158 of #LMB365 was taken while they found out more about how the building functions.
LMB 365 – Day 157
Day 157 of #LMB365 shows an artistic view of a ribosome engineering process created by Zakir Tnimov and Wolfgang Schmied in Jason Chin’s group. This ‘stapled’ ribosome has subunits linked by an RNA hinge and can be evolved for synthetic polymer synthesis in cells.
LMB 365 – Day 156
How do cells distinguish normal proteins from defective proteins and selectively get rid of the latter? This is one of the questions Manu Hegde’s lab is trying to answer because problems in getting rid of defective proteins can lead to neurodegeneration. In this microscope image of two cells for day 156 of #LMB365, normal and defective versions of the same protein are visualised in red and green, respectively. The cell keeps the normal protein on the cell surface, where it belongs, but most of the defective protein is found in degradation compartments called lysosomes. How cells know to remove only the defective proteins from the cell surface is being investigated by Eszter Zavodszky in the Hegde lab.
LMB 365 – Day 155
On day 155 of #LMB365 it appears the LMB bees have been busy. This is a honey frame from one of our hives two thirds full and capped over. Once full this can be extracted and the honey bottled ready for use. We hope to have LMB honey available during 2019!