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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

Aggregation of proteins on cell surface triggers rapid uptake and degradation

Published on 24 February, 2023

Using a combination of light microscopy and biochemical assays, Harvey McMahon’s group, in the LMB’s Neurobiology Division, have identified aggregation-dependent endocytosis (ADE) as the pathway by which cells respond to surface perturbations.

New computational method for genome analysis

Published on 20 February, 2023

Julian Gough’s group, in the LMB’s Structural Studies Division, has designed a computational method for genome analysis capable of making knowledge-based predictions directly from a human genome.

HIV-1 needs the cell metabolite IP6 to build its capsid and infect cells

Published on 9 January, 2023

In an international collaboration led by Leo James’ group, researchers have discovered that HIV-1 builds its capsid using a metabolite called IP6 that it captures from cells with a net-like protein lattice. Disabling this capture mechanism prevents capsid construction and renders HIV-1 non-infectious.

Integrin-mediated T helper 2 cell clustering revealed as key step and potential therapeutic target in allergic immune response

Published on 22 December, 2022

Researchers in Andrew McKenzie’s group, in the LMB’s PNAC Division, have used high-throughput CRISPR screening to identify a role for alpha V beta 3 integrin in IL-13 production which contributes to unwanted inflammation during an asthma or allergic immune response.

DNA replication initiation shapes the evolution and expression of the human genome

Published on 10 November, 2022

One of the universal events in the lifecycle of every cell is the initiation of genome duplication. Julian Sale’s group in the LMB’s PNAC Division have used high-resolution maps of human replication origins to demonstrate the mutagenic properties of DNA replication origins.

Refactoring the genetic code to create organisms protected by a genetic firewall

Published on 24 October, 2022

Jason Chin’s group refactor the genetic code to create genetically isolated organisms which cannot exchange genetic information with naturally-occurring organisms in the environment.

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