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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

How flies use smell to determine the identity and position of other flies

Published on 25 May, 2023

Researchers from Greg Jefferis’ group in the LMB’s Neurobiology Division have determined the highly specified neural mechanisms which allow Drosophila flies to identify and locate males by scent of a pheromone.

Activating the kinase protein PI3Kα revealed as a potential therapeutic target to protect and regenerate cells

Published on 24 May, 2023

New pre-clinical research in Roger Williams’ group at MRC LMB, University College London and AstraZeneca discovers an activator of PI3Ka that can protect heart cells from dying in the case of injury and accelerate the regeneration of neurons

Understanding the protein modifications behind Trim-Away protein degradation technology

Published on 17 April, 2023

Leo James’ group, in the LMB’s PNAC Division, has identified surprising protein modifications that underly Trim-Away protein degradation technology, which may explain its broad applicability to degrade almost any cellular protein.

The structure of the surface layer of the toughest bacterium known elucidated

Published on 13 April, 2023

Using electron microscopy, Tanmay Bharat’s group reveals the surface layer structure of the extremophilic bacterium, Deinococcus radiodurans.

Complete synaptic-resolution connectome of an insect larval brain

Published on 10 March, 2023

The groups of Marta Zlatic and Albert Cardona in the LMB’s Neurobiology Division have mapped the Drosophila larval brain, which contains 3016 neurons and 548,000 synapses and is the most complex brain ever mapped in its entirety.

Aggregation of proteins on cell surface triggers rapid uptake and degradation

Published on 24 February, 2023

Using a combination of light microscopy and biochemical assays, Harvey McMahon’s group, in the LMB’s Neurobiology Division, have identified aggregation-dependent endocytosis (ADE) as the pathway by which cells respond to surface perturbations.

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