Our daily cycle is controlled by a central clock known as the SCN, but it has been unclear how the network of cells that make up the SCN generate the properties that make it a strong clock. Michael Hastings’ group has identified a signalling axis that acts as a pacemaking hub.
Insight on Research
High-resolution structure of a GPCR-arrestin complex
Understanding minute structural differences in (G protein-coupled receptor) GPCR complexes could lead to the design of more efficacious drugs that have fewer side effects
Cell-invading bacteria are converted into signalling platforms that may trigger septic shock
Septic shock is a common cause of death that can be triggered by LPS, a component of the outer membrane of some bacteria. Felix Randow’s group has shown how the immune response against cytosol-invading bacteria is activated by a signalling platform built on their surface.
Brain organoids with the potential to predict drug permeability
The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides various nutrients. Madeline Lancaster’s group have now developed a new brain organoid that produces CSF and has the potential to predict whether drugs can access the brain.
Primitive genetic alphabet based on RNA and DNA
New research suggests that DNA building blocks may have coexisted with RNA at the dawn of life
First structures of α-synuclein filaments from human brain
Abnormal filaments of α-synuclein define several neurodegenerative diseases, including multiple system atrophy (MSA) and Parkinson’s disease. Michel Goedert’s and Sjors Scheres’ groups have now determined the first structures of α-synuclein filaments from human brain.