• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

  • Home
  • About LMB
  • Research
  • Research Groups
  • Students
  • Recruitment
  • Life at the LMB
  • Achievements
  • News & Events

Insight on Research

Directional loading mechanism is used by SMC complex to capture and ingest DNA

Published on 31 March, 2025

Led by postdoc Frank Bürmann, Jan Löwe’s group in the LMB’s Structural Studies Division, and Mark Dillingham’s group at the University of Bristol, have identified the mechanism the bacterial SMC complex MukBEF uses to entrap DNA ahead of loop extrusion, and found how this pathway can be inhibited by a bacteriophage protein.

Writing the LINE-1s: How does LINE-1 remodel human DNA to insert its sequence throughout the genome?

Published on 7 March, 2025

Spearheaded by postdoc George Ghanim, Kelly Nguyen’s group in the LMB’s Structural Studies Division have investigated the molecular mechanisms which allow LINE-1 to propagate throughout the genome via retrotransposition during target-primed reverse transcription.

Asgard archaea proteins reveal evolutionary secrets of membrane remodelling

Published on 11 February, 2025

Studying Asgard archaea, Buzz Baum’s group in the LMB’s Cell Biology Division and Aurelien Roux’s group at the University of Geneva, provide insights into the earliest origins of ESCRT-III and reveal how its proteins work together to remodel membranes.

Newly identified quality control mechanism of RNA Polymerase II transcription

Published on 11 December, 2024

Ana Tufegdžić Vidaković’s group, in the LMB’s PNAC Division, have worked with Scott Berry’s group, at the University of New South Wales, to identify the mechanism cells use to regulate gene expression via control of quality and quantity of Pol II molecules.

Discovery of a factor that accelerates protein deliveries to the endoplasmic reticulum

Published on 29 November, 2024

Huping Wang and Manu Hegde, in the LMB’s Cell Biology Division, have found a factor that helps nascent secretory and membrane proteins quickly access the protein translocation machinery when they arrive at the endoplasmic reticulum.

Cryo-ET reveals new molecular insights into tau pathology in Alzheimer’s disease

Published on 26 November, 2024

Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division have used cryo-ET to discover that tau filaments are tethered to the membranes of extracellular vesicles in Alzheimer’s disease. These findings introduce membrane tethering of amyloid filaments as a potential target to interfere with their accumulation in disease.

  • « Go to Previous Page
  • Page 1
  • Page 2
  • Page 3
  • Page 4
  • Interim pages omitted …
  • Page 62
  • Go to Next Page »

Primary Sidebar

Search

  • Privacy & Cookies
  • Contact Directory
  • Freedom of Information
  • Site Map
Find Us
©2025 MRC Laboratory of Molecular Biology,
Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000

The MRC is part of UK Research and Innovation

Contact Us

This site uses cookies. The LMB may use cookies to analyse how you use our website. We use external analysis systems which may set additional cookies to perform their analysis. These cookies (and any others in use) are detailed in our Privacy and Cookies Policy and are integral to our website. You can delete or disable these cookies in your web browser if you wish, but then our site may not work as it is designed.