M Madan Babu’s group publishes a comprehensive model for the functional innovations of TBP.
Insight on Research
Every time a cell divides, all of its genetic material must be accurately duplicated. This process is controlled by a molecular machine known as the replisome. Joseph Yeeles’ group has now produced the highest resolution, and most complete, structure of a replisome to date.
Hearing and touch depend on the ability of sensory neurons to be activated by a force, such as pressure or vibration from sound, and then pass information on to the brain. William Schafer’s group has identified some of the key proteins that make this possible.
Alcohol consumption can indirectly cause damage to our DNA and elevate cancer risk. KJ Patel’s group in the LMB’s PNAC Division has identified a novel repair mechanism for DNA damage created by by-products of alcohol metabolism.
New study, led by Pablo Alcón and Shabih Shakeel in Lori Passmore’s group, in collaboration with KJ Patel in the PNAC Division, uncovers a unique molecular “clamp and pin” mechanism that activates the D2l complex, which then recruits enzymes that cut out damaged DNA
Corticobasal degeneration (CBD) is a neurodegenerative disease that belongs to a family of diseases called tauopathies in which the protein tau forms abnormal filaments. Sjors Scheres’ and Michel Goedert’s groups have now solved the first structures of CBD tau filaments.