Collaboration between Sjors Scheres’ (Structural Studies), Benjamin Ryskeldi-Falcon’s and Michel Goedert’s (both Neurobiology) groups have used cryo-EM to reveal structures of Aβ42 filaments, the key factor behind the pathogenesis of Alzheimer’s disease.
Insight on Research
Cryo-EM analysis of TDP-43 filaments by Benjamin Ryskeldi-Falcon’s group in the LMB’s Neurobiology Division has revealed the atomic structure of the characterising feature of neurodegenerative diseases ALS and FTD.
DNA damage caused by formaldehyde is repaired involving CSA and CSB genes. KJ Patel’s lab have shown how, when this pathway is mutated such as in people with Cockayne syndrome, the appetite suppression hormone GDF15 is released leading to severe weight loss.
Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation.
Cryo-EM analysis reveals structure of structural maintenance of chromosomes (SMC) complex, and shows for the first time how the protein machinery entraps two DNA helices simultaneously in order to individualise chromosomes.
Electron cryo-microscopy continues to be a pivotal method for structural biology. Chris Russo’s group, in the LMB’s Structural Studies Division, share an optimisation process to meet increasing demand for cryo-EM grids.