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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

In-cell structure elucidation reveals a functional significance of microbial S-layers in critical global geochemical cycles

Published on 29 May, 2024

Tanmay Bharat’s group, in the LMB’s Structural Studies Division, reveals the surface layer structure of the archaeon Nitrosopumilus maritimus, crucial to the global nitrogen cycle.

First map of the neurotransmitters used in the fruit fly brain

Published on 21 May, 2024

Greg Jefferis’ group in the LMB’s Neurobiology Division, in collaboration with scientists at the Janelia Research Campus, have predicted the sign of each synapsis in the fruit fly brain.

ModelAngelo software expands cryo-EM toolkit with faster atomic model building and identification of novel proteins

Published on 16 April, 2024

Kiarash Jamali, a Ph.D. student in Sjors Scheres’ group in the LMB’s Structural Studies Division, has designed a new machine learning software capable of fast, accurate model building at atomic levels and identification of new proteins beyond previous capabilities.

Structure of γ-Tubulin Ring Complex provides insights into nucleation process behind microtubule formation

Published on 15 April, 2024

David Barford’s group, in the LMB’s Structural Studies Division, in collaboration with John Kilmartin in the LMB’s Cell Biology Division, have used electron cryo-tomography and sub-tomogram averaging to determine the structure of native γTuRC capping microtubules from extracted Spindle Pole Bodies.

New 3D embryonic stem cell culture system sheds light on gastrulation mechanism

Published on 4 April, 2024

Marta Shahbazi’s group in the LMB’s Cell Biology Division has developed a three-dimensional embryonic stem cell culture system to study the molecular motivations behind basal delamination where cells change shape and move from their tissue of origin.

A genome-wide resource for dissecting transport within cells

Published on 12 March, 2024

Chun Hao Wong and Simon Bullock, from the LMB’s Cell Biology Division, together with Douglas Ross-Thriepland and colleagues at AstraZeneca, have systematically disrupted every gene in cultured human cells to reveal a large number of new factors required for organisation of cells by the microtubule motor dynein.

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