Lalita Ramakrishnan’s group, LMB Cell Biology Division and University of Cambridge Molecular Immunity Unit, has determined that increased metabolism, prompted through mTOR kinase, is a crucial resistance factor against macrophage necrosis during TB infection.
Insight on Research
Identical structures of α-synuclein filaments from Parkinson’s disease and dementia with Lewy bodies
The groups of Michel Goedert and Sjors Scheres, from the LMB’s Neurobiology and Structural Studies Divisions, have used cryo-EM to identify identical structures of α-synuclein filaments from Parkinson’s disease and dementia with Lewy bodies.
Cryo-EM reveals first high-resolution structure of the dynein-dynactin complex bound to microtubules
New structure from Andrew Carter’s group in the LMB’s Structural Studies Division reveals dynein’s interaction with microtubules and how cargo adaptors use conserved sequence motifs to scaffold the motor protein complex
Mammalian clock gene Cryptochrome 1 is crucial to suprachiasmatic nucleus timekeeping
Using translational switching, Michael Hastings’ group has shown that the mammalian clock gene Cryptochrome 1 is a state variable and core phase setting component of the brain’s master clock.
New analysis approach to identify pathogenesis of Mycobacterium abscessus
Andres Floto’s group in the University of Cambridge’s Molecular Immunity Unit, housed at the LMB, have developed phenogenomic analysis – a combination of phenotyping and whole genome sequencing – as a new approach to reveal insights into bacterial pathobiology.
Cryo-EM structure of a cholinergic cell membrane reveals importance of cholesterol in neuromuscular transmission
Structural study by Nigel Unwin in the LMB’s Neurobiology Division, has found that lipids of cell membranes can form ordered, hydrophobic ‘skins’ in regions of high cholesterol concentration.