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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

Unravelling the replisome: how a molecular machine overcomes obstacles to DNA replication

Published on 4 May, 2020

Every time a cell divides, all of its genetic material must be accurately duplicated. This process is controlled by a molecular machine known as the replisome. Joseph Yeeles’ group has now produced the highest resolution, and most complete, structure of a replisome to date.

Ankyrins: a missing molecular link in mechanical senses

Published on 22 April, 2020

Hearing and touch depend on the ability of sensory neurons to be activated by a force, such as pressure or vibration from sound, and then pass information on to the brain. William Schafer’s group has identified some of the key proteins that make this possible.

How alcohol-derived DNA damage is fixed

Published on 4 March, 2020

Alcohol consumption can indirectly cause damage to our DNA and elevate cancer risk. KJ Patel’s group in the LMB’s PNAC Division has identified a novel repair mechanism for DNA damage created by by-products of alcohol metabolism.

How is the Fanconi Anaemia pathway activated to remove DNA lesions?

Published on 17 February, 2020

New study, led by Pablo Alcón and Shabih Shakeel in Lori Passmore’s group, in collaboration with KJ Patel in the PNAC Division, uncovers a unique molecular “clamp and pin” mechanism that activates the D2l complex, which then recruits enzymes that cut out damaged DNA

A novel tau fold in the neurodegenerative disease corticobasal degeneration

Published on 13 February, 2020

Corticobasal degeneration (CBD) is a neurodegenerative disease that belongs to a family of diseases called tauopathies in which the protein tau forms abnormal filaments. Sjors Scheres’ and Michel Goedert’s groups have now solved the first structures of CBD tau filaments.

How two proteins work together in DNA damage detection

Published on 7 February, 2020

Detection of DNA damage requires a quick response and dynamic regulation of proteins. Better understanding how DNA repair pathways are initiated could have great clinical implications, particularly for cancer therapy. A team of scientists, including members of David Neuhaus’ group at the LMB, led by Ivan Ahel at the University of Oxford, has now visualised the interaction between two proteins, PARP and HPF1, to show how they work together to initiate DNA repair.

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