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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

New pathway for cells to detect bacterial infection

Published on 6 July, 2023

Felix Randow’s group, in the LMB’s PNAC Division, have discovered TECPR1 as a novel E3 ligase, which, when sensing sphingomyelin on damaged membranes, conjugates the ubiquitin-like autophagy protein LC3 to those membranes.

Pore-forming protein perforin-2 is critical to immune response by dendritic cells

Published on 23 June, 2023

Patrycja Kozik’s group, in the LMB’s PNAC Division, find that the pore-forming protein perforin-2 is an effector of antigen escape in dendritic cells – a critical component to T cell mediated immune responses.

Antiviral Bicycles are effective against SARS-CoV-2

Published on 16 June, 2023

A collaborative study including researchers in Leo James’ group in the LMB’s PNAC Division and Bicycle Therapeutics has developed a new class of antivirals which can be combined together like building blocks to effectively immobilise COVID-19’s Spike protein and block infection.

Neuroprotective protein ADNP is vital to immune reactions to allergens

Published on 7 June, 2023

Using high-throughput CRISPR screening, researchers in Andrew McKenzie’s group in the LMB’s PNAC Division have identified a previously unknown immune-related role for ADNP and identified the molecular mechanism by which it regulates IL-13 expression in allergic immune responses.

How flies use smell to determine the identity and position of other flies

Published on 25 May, 2023

Researchers from Greg Jefferis’ group in the LMB’s Neurobiology Division have determined the highly specified neural mechanisms which allow Drosophila flies to identify and locate males by scent of a pheromone.

Activating the kinase protein PI3Kα revealed as a potential therapeutic target to protect and regenerate cells

Published on 24 May, 2023

New pre-clinical research in Roger Williams’ group at MRC LMB, University College London and AstraZeneca discovers an activator of PI3Ka that can protect heart cells from dying in the case of injury and accelerate the regeneration of neurons

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