MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

LMB In The News

Jefferis group publishes largest connectome of a male Drosophila brain to date

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Greg Jefferis’s group, as part of an international collaboration including the FlyEM Project Team at HHMI-Janelia, has published the first complete connectome of an entire male Drosophila central nervous system. The connectome, which is not yet peer-reviewed, includes the central brain, optic lobes and the ventral nerve cord. More…

Lori Passmore received honorary awards from Cambridge and Aarhus Universities

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Lori Passmore, Group Leader and Joint Head of the LMB’s Structural Studies Division, has been appointed Honorary Professor of the University of Cambridge and received an Honorary Doctorate from Aarhus University in Denmark. Lori is an Official Fellow of Clare Hall College, Cambridge and has collaborated closely with Aarhus University since launching her independent research […]

Generating paired helical filaments (PHFs) in vitro presents new opportunities for Alzheimer’s research

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Research spearheaded by Sofia Lövestam in Michel Goedert and Sjors Scheres’ groups has identified a combination of 12 residues in tau which, when mutated in vitro, prompt the formation of paired helical filaments (PHFs), the distinctive hallmark of advanced Alzheimer’s disease. Interestingly, in the engineered tau, named PAD12, the residues in question are all outside […]