As previously seen in tau and α-synuclein, Benjamin Ryskeldi-Falcon’s group have determined that TDP-43 forms distinct amyloid arrangements in different neurodegenerative diseases. They describe the structure of filaments of TDP-43 in frontotemporal lobar degeneration (FTLD) as a chevron shape, markedly different from the double spiral shape they previously identified from brains of those with a form […]
LMB In The News
The ‘Unknome’ genes which make up a fifth of the human genome
Sean Munro’s group in the LMB’s Cell Biology Division, and Matthew Freeman at the Dunn School of Pathology, University of Oxford, have built the ‘Unknome’ database, which ranks human genes based on how much is known about them. They found that surprisingly little is known about an estimated fifth of the human genome, and that […]
The Chin group unveils gene synthesis breakthrough
Business Weekly cover recent research from Jason Chin’s group in the LMB’s PNAC Division which details their new technologies for continuous genome synthesis. They also include comment from Constructive Bio, a spinout company founded by Jason Chin, who expand on the application possibilities for this research. More…
Great British Railway Journeys visits LMB to learn about the significance of the discovery of the structure of DNA
At the end of his Brandon to Cambridge railway journey, Michael Portillo visits the LMB to talk to Venki Ramakrishnan about the significance of the discovery of the double helix structure of DNA by James Watson and Francis Crick. Venki shares how the team solved this puzzle by combining data from various sources, including X-Ray […]
Secretary of State visits the LMB
The LMB recently hosted a visit from Chloe Smith, Secretary of State for Science, Innovation and Technology, where she was shown the latest electron cryo-microscope, installed as part of the government’s World Class Labs investment. During the visit, Chloe Smith spoke to LMB Director Jan Löwe, discussed how LMB researchers use electron cryo-microscopy to look […]
Lori Passmore on her research career so far, the benefits of collaboration, and her greatest achievement away from the lab
Lori Passmore, Group Leader in the LMB’s Structural Studies Division, chats to The FEBS Journal about her research career to date, including the technological advancements with electron cryo-microscopy, her favourite finding so far, and what advice she would give to early career scientists. More…