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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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LMB In The News

Redefining human brain temperature and its clinical utility

Published on 27 June, 2022

Magnetic resonance spectroscopy allowed Nina Rzechorzek (member of the O’Neill group, Cell Biology) and collaborators to create a HEATWAVE map, showing how temperatures vary in the brain across the day, between the sexes, and as we age – a healthy brain is remarkably hotter than previously assumed. More…

Michel Goedert discusses his life and career in research with DZNE

Published on 16 May, 2022

To mark the award of the Hartwig Piepenbrock-DZNE Prize for his ground-breaking research into the molecular basis of neurodegenerative diseases, DZNE have released a video portrait of Michel Goedert, Group Leader in the LMB’s Neurobiology Division. More…

LMB in vitro testing highlights bicyclic peptides (Bicycle®) as potential antiviral compounds against SARS-CoV-2

Published on 28 April, 2022

Bicycle Therapeutics reports on its updated preclinical data produced in collaboration with Leo James’ group in the LMB’s PNAC Division. In vitro tests of their proprietary bicyclic peptide show promise for antiviral modality against SARS-CoV-2. More…

LMB research featured in summary of three cryo-EM studies of TMEM106b fibrils found in neurodegenerative diseases

Published on 13 April, 2022

Alzforum summarises three recent papers which analysed TMEM106b amyloid filaments in the human brain – including research from Sjors Scheres’ and Michel Goedert’s groups in the LMB’s Structural Studies and Neurobiology Divisions respectively. More…

Structural analysis of GABAA receptors reveals unexpected diversity of arrangements

Published on 8 April, 2022

The Cambridge Independent reports on a recent paper from Radu Aricescu’s group in the LMB’s Neurobiology Division. His group’s structural investigation into type A gamma-aminobutyric acid receptors has found that their subunit arrangements are far more varied than previously thought. More…

Brad Amos on microscopy design, writing LMB Christmas skits, and diving with sharks

Published on 11 March, 2022

Emeritus scientist Brad Amos is a guest on The Microscopists podcast from Bitesize Bio. Listen to him chat to host Peter O’Toole about his career, experience with microscope design, and insights into the annual LMB Christmas skit. More…

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