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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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LMB In The News

Team of the Year for LMB’s Biological Services Group in the Janet Wood Innovation Awards

Published on 29 September, 2025

The award recognises the quarantine unit for their outstanding contribution to research and animal welfare. The dedicated team carries out a wide range of regulated procedures and their proactive approach to refinement has led to the introduction of improved surgical techniques and the use of extra enrichment. More…

Generating paired helical filaments (PHFs) in vitro presents new opportunities for Alzheimer’s research

Published on 19 September, 2025

Research spearheaded by Sofia Lövestam in Michel Goedert and Sjors Scheres’ groups has identified a combination of 12 residues in tau which, when mutated in vitro, prompt the formation of paired helical filaments (PHFs), the distinctive hallmark of advanced Alzheimer’s disease. Interestingly, in the engineered tau, named PAD12, the residues in question are all outside […]

The “gargantuan effort” to recode life with just 57 codons

Published on 11 August, 2025

NewScientist speak to Wes Robertson, Group Leader in the LMB’s PNAC Division, about his work in Jason Chin’s group to synthesise E. coli using just 57 codons, rather than the usual 64. More…  

LMB announced as one of 12 UK institutions selected to deliver the government’s Global Talent Fund

Published on 18 July, 2025

LMB is one of 12 of the UK’s leading universities and research institutions, across all 4 nations, selected to deliver the Global Talent Fund: a £54 million investment in Britain’s future prosperity and economic growth. More…

Alan Fersht and Wes Robertson discuss the past, present and future of protein studies

Published on 4 July, 2025

The Naked Scientists podcast covers all things protein, including speaking to Alan Fersht and Wes Robertson from the LMB’s PNAC Division. They cover how early advances at the LMB revolutionised the field of protein studies, and how protein design could be developed to address key concerns in health and the environment. More…

First patient treated for APDS, a rare inherited disorder identified by collaborative Cambridge team including Roger Williams’s group

Published on 27 June, 2025

In 2013, Roger Williams’s group in the LMB’s PNAC Division published findings from a study conducted with researchers at the University of Cambridge, the Babraham Institute and clinicians from Addenbrooke’s Hospital. Together, the team identified a rare genetic mutation which causes a condition now known as Activated PI3K-d Syndrome (APDS), which weakens the immune system […]

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