John Sulston is best known for the leading role he played in the Human Genome Project. But earlier in his career, while working at the LMB, he studied the development of the nematode worm. Sarah Harrop tells the story behind a lab notebook entry which contributed to a Nobel Prize-winning breakthrough. More…
LMB In The News
The revolution will not be crystallized: a new method sweeps through structural biology
“Move over X-ray crystallography. Electron cryo-microscopy is kicking up a storm by revealing the hidden machinery of the cell” – this Nature News Feature highlights the work of the LMB’s Richard Henderson, Nigel Unwin and Sjors Scheres in developing cryo-EM techniques that are changing the way scientists solve molecular structures. More…
Orchestrating Organoids
Madeline Lancaster’s method of growing organoids to understand early brain development is featured in this “guide to crafting tissues in a dish that reprise in vivo organs” More…
Worming our way to a new understanding of behaviour
The wriggling and writhing of worms may hold clues to the inner workings of our brains, according to scientists at the MRC’s Clinical Sciences Centre and their collaborators at the LMB. The researchers have developed a pioneering tool to analyse a worm’s posture as it wriggles, and will use the tool to investigate how exactly […]
From tool to therapy: a timeline of monoclonal antibody technology
Abstract: They started out as a useful tool for studying the immune system in the lab and now they’re a family of drugs treating millions of patients, with global revenues of nearly $75 billion in 2013. MRC funding and researchers have been entwined with the monoclonal antibodies story from the very beginning. Forty years ago […]
The MORPHEUS II protein crystallization screen
Fabrice Gorrec from the LMB has published developments related to MORPHEUS II – a protein crystallization screen. He has demonstrated that additives selected from the PDB that are under-represented in traditional screens can be combined to formulate suitable and useful conditions, not only for crystallization but the overall structure determination process. More