This photo for day 257 of #LMB365 was taken from Hobson’s Park, south-west of the LMB, which is part of the Great Kneighton development.
LMB 365 – Day 257
LMB 365 – Day 256
KDEL is the sorting signal for luminal ER proteins. In this a classic experiment for day 256 of #LMB365, lysozyme was expressed in COS cells without (left) or with (right) the addition of the sequence SEKDEL, and detected by immunofluorescence. Normally, lysozyme is rapidly secreted and the main pool of intracellular protein is in transit through the Golgi apparatus. Addition of KDEL causes it to accumulate to high levels in the ER. This was the original proof that (SE)KDEL is a sufficient signal for ER retention.
Two LMB scientists shortlisted for Cambridge Independent’s ‘Researcher of the Year’ award
This year’s Science and Technology Awards, run by Cambridge’s weekly newspaper, feature Benjamin Falcon from Neurobiology Division and Julius Fredens from Protein and Nucleic Acid Division as finalists. The ‘Researcher of the Year’ winner, out of a shortlist of six, will be announced at an awards ceremony at the Bradfield Centre. More…
LMB 365 – Day 255
This image for day 255 of #LMB365 shows our Head of Scientific Computing donating the LMB’s old line printer to the Centre for Computing History (CCH) in Cambridge http://www.computinghistory.org.uk/. The printer was bought in 1991 for £8,125 and has been in constant use until very recently… Before graphics terminals became so sophisticated and image processing so automated, the LMB’s line printer gave essential output of large scale images and transforms for manual analysis of helical assemblies, such as tubes of the acetylcholine receptor
LMB 365 – Day 254
Day 254 of #LMB365 showsa reflection of the LMB in the nearby AstraZeneca building at sunset. We wonder whether they can see similar reflections of their building in the glass façade of our building?
What is the best time for a heart surgery?
And why does it matter? BBC writes about the role circadian rhythms plays in how our bodies respond to injuries, infections and healing, including work by John O’Neill’s group on tissue repair damage and biological time. More…