Structure of the outer kinetochore bound to microtubules, determined by David Barford’s group in the Structural Studies Division, reveals how phosphorylation regulates mitotic spindle chromosome attachment errors to ensure DNA is equally segregated into two daughter cells.
Molecular mechanics of mitotic error correction revealed by cryo-EM
Cheaper microscope could bring protein mapping technique to the masses
A news piece in Science highlights how Chris Russo’s group and Richard Henderson, both in the LMB’s Structural Studies Division, have worked with other collaborators to build a new cryo–electron microscope at a fraction of the size and costs of current suppliers. More…
Discovery of a new amyloid-forming protein in neurodegenerative disease
The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.
A success for the Raymond Nicolet Trust charity cake sale at the LMB
The Raymond Nicolet Trust organised a charity cake sale at the LMB on Monday 21st November. Volunteer patisserie amateurs baked a variety of different cakes and successfully raised £248.75. All proceedings are going to support The Sveti Sava Elementary School, Bajina Basta in Serbia. Thank you so much to everyone who helped! More…
Bart Barrell (1944-2023)
Bart Barrell, former Group Leader in the LMB’s PNAC Division and later co-founder of the Wellcome Sanger Centre, has died aged 79.
Low energy cryo-EM to widen accessibility for fast and accurate structure determination
A collaborative team lead by Chris Russo’s group in the LMB’s Structural Studies Division has developed a new electron cryo-microscope, capable of solving atomic structures at a fraction of the energy and cost of existing models.