While filaments of either tau or TDP-43 underlie 90% of frontotemporal dementia cases, the proteopathic culprits behind the remaining 10 percent have eluded researchers. Fused in sarcoma (FUS) often forms inclusions in such cases, hence Benjamin Ryskeldi-Falcon’s group and collaborators expected to find FUS fibrils when they put samples from these patients’ brains through the […]
Sought FUS, Found TAF—A New Fibril in Frontotemporal Dementia
Celebrating Michel Goedert’s four decades at the LMB
Congratulations to Michel Goedert, Group Leader in the LMB’s Neurobiology Division, who has reached 40 years of service at the LMB.
The band and the rhythm
The latest episode of The EMBO podcast features John O’Neill and Andrew Beale, Group Leader and postdoctoral researcher in the LMB’s Cell Biology Division. They talk about how investigating a mysterious band on a western blot led to a new understanding of the red blood cell’s clockwork mechanism. Read more…
Molecular mechanics of mitotic error correction revealed by cryo-EM
Structure of the outer kinetochore bound to microtubules, determined by David Barford’s group in the Structural Studies Division, reveals how phosphorylation regulates mitotic spindle chromosome attachment errors to ensure DNA is equally segregated into two daughter cells.
Cheaper microscope could bring protein mapping technique to the masses
A news piece in Science highlights how Chris Russo’s group and Richard Henderson, both in the LMB’s Structural Studies Division, have worked with other collaborators to build a new cryo–electron microscope at a fraction of the size and costs of current suppliers. More…
Discovery of a new amyloid-forming protein in neurodegenerative disease
The discovery of TAF15 amyloid filaments in patients with frontotemporal lobar degeneration by the group of Benjamin Ryskeldi-Falcon in the LMB’s Neurobiology Division establishes this protein as a diagnostic and therapeutic target for this neurodegenerative disorder.