Artavanis-Tsakonas: LMB 1971-1974, PhD student, PNACGreenwald: LMB 1983-1986, Postdoctoral Visitor, Cell BiologyStruhl: LMB 1976-1982; PhD student; Scientific Staff, Cell Biology The three alumni received the prize for their work on Notch signalling, identifying it as a fundamental cell communication pathway which governs cell fate decisions and, when dysregulated, is implicated in several diseases including neurodegeneration […]
Spyros Artavanis-Tsakonas, Iva Greenwald and Gary Struhl share 2025 Canada Gairdner International Award
Cytosol-adapted bacterium usurps host defence mechanism to evade LPS ubiquitylation
Felix Randow’s group, in the LMB’s PNAC Division, has identified the mechanism by which cytosol-dwelling Shigella flexneri bacteria use their effector protein IpaH1.4 to avoid LPS ubiquitylation by degrading the host E3 ligase RNF213.
Benjamin Ryskeldi-Falcon awarded The Colworth Medal from the Biochemical Society
Benjamin Ryskeldi-Falcon, Group Leader in the LMB’s Neurobiology Division, has been recognised for his research into the molecular basis of neurodegenerative diseases.
LMB highlights the scale of molecular biology at the Cambridge Festival
LMB scientists showcased their work at the Cambridge Festival with a hands-on activity about the molecular mechanisms of behaviour and science and art collaboration about body clocks.
Directional loading mechanism is used by SMC complex to capture and ingest DNA
Led by postdoc Frank Bürmann, Jan Löwe’s group in the LMB’s Structural Studies Division, and Mark Dillingham’s group at the University of Bristol, have identified the mechanism the bacterial SMC complex MukBEF uses to entrap DNA ahead of loop extrusion, and found how this pathway can be inhibited by a bacteriophage protein.
LMB spinout TRIMTECH Therapeutics will develop targeted protein degraders to treat neurodegenerative conditions
Leo James co-founds new UK biotech company together with Will McEwan (UK DRI at Cambridge) leveraging the unique properties of TRIM21, discovered at the LMB.