This image for day 324 of #LMB365 shows a cryo-EM visualisation of a G protein-coupled receptor reconstituted into a lipid nanodisc and then coupled to beta-arrestin from Chris Tate’s group in the Structural Studies Division
LMB 365 – Day 324
LMB 365 – Day 323
Asymmetric cell division is the process by which one cell gives rise to two daughters that have different fate. Asymmetric cell division is the hallmark of stem cells, which generate all the different cell types in the organism. The Derivery Lab in the Cell Biology Division uses the fruit fly to study the molecular mechanism of asymmetric cell division as it is amenable to imaging and genetic modifications. This image for day 323 of #LMB365 represents the back of the fly (called the notum), where all the cells express a cytoskeleton marker in green, while only the cells dividing asymmetrically express a red marker. These cells form a remarkable aligned array, which will give rise to the mechanosensory bristles on the adult fly.
New insights into the architecture of organelle contact sites, and the sites’ roles in cellular lipid fluxes
By combining fluorescence microscopy and electron tomography, Wanda Kukulski’s lab in Cell Biology Division has visualised protein structures that bridge contact sites between the endoplasmic reticulum and plasma membrane in yeast, in their native environment i.e. within the cell.
LMB 365 – Day 322
Day 322 of #LMB365 shows Li Jin and Christine Hilcenko setting up their stand at the LMB for a charity cake sale in support of The Raymond Nicolet Trust. The sale achieved an amazing £178 that will fully go to support educational establishments in Serbia.
LMB 365 – Day 321
If you have ever wondered how all the glass in the atrium of the LMB is kept clean, this photo for day 321 of #LMB365 shows you how. This is carried out biennially and takes two people 8 days to clean all the glass, including the fascia boards, high girders, tops of pods, and floodlights. Throughout the process care is taken to protect the atrium floor.
LMB 365 – Day 320
On day 320 of #LMB365 we have a picture by Katja Röper in the Cell Biology Division. This image shows a confocal image of the forming tube of the salivary glands in a Drosophila embryo, a model system for the formation of tubular organs. Tube cells are in green, and this forming tube is aberrant and forked due to a specific genetic mutation affecting tube formation. The Röper lab studies how important tubular organs from flies to humans form during development.