Dale H.J.A., Sutherland J.D.
Indirect formation of peptide bonds as a prelude to ribosomal transpeptidation
J Am Chem Soc 147(1):305-317DOI: 10.1021/jacs.4c10326
PMID: 39693575
PMCID: PMC11726440
Date of Paper: 08/01/2025
Division: Protein & Nucleic Acid ChemistryMaldutyte J., Li X.H., Gomez-Navarro N., Robertson E.G., Miller E.A.
ER export via SURF4 uses diverse mechanisms of both client and coat engagement
The Journal of Cell Biology 224(1):e202406103DOI: 10.1083/jcb.202406103
PMID: 39531033
PMCID: PMC11557686
Date of Paper: 06/01/2025
Division: Cell BiologyConflitti P., Lyman E., Sansom M.S.P., Hildebrand P.W., Gutiérrez-de-Terán H., Carloni P., Ansell T.B., Yuan S., Barth P., Robinson A.S., Tate C.G., Gloriam D., Grzesiek S., Eddy M.T., Prosser S., Limongelli V.
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery
Nature reviews. Drug DiscoveryDOI: doi.org/10.1038/s41573-024-01083-3
PMID: 39747671
PMCID:
Date of Paper: 02/01/2025
Division: Structural StudiesKrüger L.K., Watson J.L., Derivery E.
Synthetic engineering of cortical polarity during mitosis using designed proteins
Methods in Molecular Biology 2872:247-255DOI: 10.1007/978-1-0716-4224-5_17
PMID: 39616581
PMCID:
Date of Paper: 01/01/2025
Division: Cell BiologyGutfreund C., Betz K., Abramov M., Coosemans F., Holliger P., Herdewijn P., Marx A.
Structural insights into a DNA polymerase reading the xeno nucleic acid HNA
Nucleic Acids Research 53(1):gkae1156DOI: doi.org/10.1093/nar/gkae1156
PMID: 39673482
PMCID: PMC11724289
Date of Paper: 01/01/2025
Division: Protein & Nucleic Acid ChemistryMurat P., Guilbaud G., Sale J.E.
DNA replication initiation drives focal mutagenesis and rearrangements in human cancers
Nature Communications 15(1):10850DOI: doi.org/10.1038/s41467-024-55148-3
PMID: 39738026
PMCID: PMC11685606
Date of Paper: 30/12/2024
Division: Protein & Nucleic Acid ChemistryChan Z.C.K., Qi C., Cai Y., Li X., Ren J.
Revealing and mitigating the inhibitory effect of serotonin on HRP-mediated protein labelling
Scientific Reports 14(1):32126DOI: doi.org/10.1038/s41598-024-83928-w
PMID: 39738643
PMCID: PMC11686078
Date of Paper: 30/12/2024
Division: Neurobiologyde Veer S.J., Craik D.J., Rehm F.B.H.
Highly efficient transpeptidase-catalyzed isopeptide ligation
Journal of the American Chemical SocietyDOI: doi.org/10.1021/jacs.4c11964
PMID: 39714948
PMCID: PMC11726557
Date of Paper: 23/12/2024
Division: Protein & Nucleic Acid ChemistrySun J., Rojo-Cortes F., Ulian-Benitez S., Forero M.G., Li G., Signh D.N.D., Wang X., Cachero S., Moreira M., Kavanagh D., Jefferis G.S.X.E., Croset V., Hidalgo A.
A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
Elife 13:RP102222DOI: doi.org/10.7554/elife.102222
PMID: 39704728
PMCID: PMC11661795
Date of Paper: 20/12/2024
Division: NeurobiologySpinck M., Guppy A., Chin J.W.
Automated orthogonal tRNA generation
Nature Chemical BiologyDOI: doi.org/10.1038/s41589-024-01782-3
PMID: 39706894
PMCID:
Date of Paper: 20/12/2024
Division: Protein & Nucleic Acid ChemistrySenn K.A., Lipinski K.A., Zeps N.J., Griffin A.F., Wilkinson M.E., Hoskins A.A.
Control of 3' splice site selection by the yeast splicing factor Fyv6
Elife 13:RP100449DOI: doi.org/10.7554/elife.100449
PMID: 39688371
PMCID: PMC11651659
Date of Paper: 17/12/2024
Division: Structural StudiesDu Y., Zuber P.K., Xiao H., Li X., Gordiyenko Y., Ramakrishnan V.
Efficient circular RNA synthesis for potent rolling circle translation
Nature Biomedical EngineeringDOI: doi.org/10.1038/s41551-024-01306-3
PMID: 39672985
PMCID:
Date of Paper: 13/12/2024
Division: Structural StudiesOchner H., Böhning J., Wang Z., Tarafder A.K., Caspy I., Bharat T.A.M.
Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Plos Pathogens 20(12):e1012773DOI: doi.org/10.1371/journal.ppat.1012773
PMID: 39666767
PMCID: PMC11670995
Date of Paper: 12/12/2024
Division: Structural StudiesBirtele M., Lancaster M., Quadrato G.
Modelling human brain development and disease with organoids
Nature reviews. Molecular Cell BiologyDOI: doi.org/10.1038/s41580-024-00804-1
PMID: 39668188
PMCID:
Date of Paper: 12/12/2024
Division: Cell BiologyJames N.R., O'Neill J.S.
Circadian control of protein synthesis
Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology :e202300158DOI: doi.org/10.1002/bies.202300158
PMID: 39668398
PMCID:
Date of Paper: 12/12/2024
Division: Cell BiologyCacioppo R., Gillis A., Shlamovitz I., Zeller A., Castiblanco D., Crisp A., Haworth B., Arabiotorre A., Abyaneh P., Bao Y., Sale J.E., Berry S., Tufegdžić Vidaković A.
CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
Molecular Cell 84(24):4808-4823.e13DOI: doi.org/10.1016/j.molcel.2024.11.024
PMID: 39667934
PMCID:
Date of Paper: 11/12/2024
Division: Protein & Nucleic Acid ChemistryBai Y., Mercadé I.D., Elgendy R., Lambiase G., Peak-Chew S., Franco C., Wingett S.W., Stevens T.J., Grassi L., Hitchcock N., Ferreira C.S., Hatton D., Miller E.A., Mistry R.K.
Identification of cellular signatures associated with chinese hamster ovary cell adaptation for secretion of antibodies
Computational and Structural Biotechnology Journal 27:17-31DOI: doi.org/10.1016/j.csbj.2024.12.006
PMID: 39760073
PMCID: PMC11697065
Date of Paper: 10/12/2024
Division: Cell Biology, Facilities (MassSpec)van Hoorn C., Carter A.P.
A cryo-electron tomography study of ciliary rootlet organization
Elife 12:RP91642DOI: doi.org/10.7554/elife.91642
PMID: 39641991
PMCID: PMC11623930
Date of Paper: 06/12/2024
Division: Structural Studiesda Silva Pereira J.A., de Souza G.P., Virgilio-da-Silva J.V., Prodonoff J.S., de Castro G., Pimentel L.F., Mousovich-Neto F., Davanzo G.G., Aguiar C.F., Breda C.N.S., Guereschi M.G., Araújo R.C., Mori M.A., Câmara N.O.S., Souza D.P., Basso A.S., Moraes-Vieira P.M.
LXR regulation of adipose tissue inflammation during obesity is associated with dysregulated macrophage function
Obesity (Silver Spring, Md.) 33(1):78-90DOI: doi.org/10.1002/oby.24158
PMID: 39632389
PMCID:
Date of Paper: 04/12/2024
Division: Cell BiologyBabai K.H., Long F., Malý M., Yamashita K., Murshudov G.N.
Improving macromolecular structure refinement with metal-coordination restraints
Acta crystallographica. Section D, Structural Biology 80(Pt 12):821-833DOI: 10.1107/s2059798324011458
PMID: 39625466
PMCID: PMC11626771
Date of Paper: 03/12/2024
Division: Structural StudiesBu F., Adam Y., Adamiak R.W., Antczak M., de Aquino B.R.H., Badepally N.G., Batey R.T., Baulin E.F., Boinski P., Boniecki M.J., Bujnicki J.M., Carpenter K.A., Chacon J., Chen S.J., Chiu W., Cordero P., Das N.K., Dad R., Dawson W.K., DiMaio F., Ding F., Dock-Bregeon A.C., Dokholyan N.V., Dror R.O., Dunin-Horkawicz S., Eismann S., Ennifar E., Esmaeeli R., Farsani M.A., Ferré-D'Amaré A.R., Geniesse C., Ghanim G.E., Guzman H.V., Hood I.V., Huang L., Jain D.S., Jaryani F., Jin L., Joshi A., Karelina M., Kieft J.S., Kladwang W., Kmiecik S., Koirala D., Kollmann M., Kretsch R.C., Kurciński M., Li J., Li S., Magnus M., Masquida B., Moafinejad S.N., Mondal A., Mukherjee S., Nguyen T.H.D., Nikolaev G., Nithin C., Nye G., Jeyeram I.P.N.P., Perez A., Pham P., Piccirilli J.A., Pilla S.P., Pluta R., Poblete S., Ponce-Salvatierra A., Popenda M., Popenda L., Pucci F., Rangan R., Ray A., Ren A., Sarzynska J., Sha C.M., Stefaniak F., Su Z., Suddala K.C., Szachniuk M., Townshend R., Trachman R.H., Wang J., Wang W., Watkins A., Wirecki T.K., Xiao Y., Xiong P., Xiong Y., Yang J., Yesselman J.D., Zhang J., Zhang Y., Zhang Z., Zhou Y., Zok T., Zhang D., Zhang S., Żyła A., Westhof E., Miao Z.
RNA-Puzzles Round V: blind predictions of 23 RNA structures
Nature MethodsDOI: 10.1038/s41592-024-02543-9
PMID: 39623050
PMCID:
Date of Paper: 02/12/2024
Division: Structural StudiesNeuhaus D., Stott K.
A finger that gets in the way: When binding isn't just about the bound state
Structure (London, England : 1993) 32(12):2182-2185DOI: doi.org/10.1016/j.str.2024.11.001
PMID: 39642848
PMCID:
Date of Paper: 01/12/2024
Division: Structural StudiesWang H., Hegde R.S.
Identification of a factor that accelerates substrate release from the signal recognition particle
Science 386(6725):996-1003DOI: doi.org/10.1126/science.adp0787
PMID: 39607913
PMCID:
Date of Paper: 28/11/2024
Division: Cell BiologyZubkov N., Munro S.
New players and targets in mannose 6-phosphate-dependent lysosomal sorting
The EMBO Journal 43(24):6233-6235DOI: doi.org/10.1038/s44318-024-00310-2
PMID: 39587298
PMCID: PMC11649812
Date of Paper: 25/11/2024
Division: Cell BiologyFowler S.L., Behr T.S., Turkes E., O'Brien D.P., Cauhy P.M., Rawlinson I., Edmonds M., Foiani M.S., Schaler A., Crowley G., Bez S., Ficulle E., Tsefou E., Fischer R., Geary B., Gaur P., Miller C., D'Acunzo P., Levy E., Duff K.E., Ryskeldi-Falcon B.
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
Nature Neuroscience 28(1):40-48DOI: doi.org/10.1038/s41593-024-01801-5
PMID: 39572740
PMCID: PMC11706778
Date of Paper: 21/11/2024
Division: Neurobiology, Cell Biology