Ghetti B., Schweighauser M., Jacobsen M.H., Gray D., Bacioglu M., Murzin A.G., Glazier B.S., Katsinelos T., Vidal R., Newell K.L., Gao S., Garringer H.J., Spillantini M.G., Scheres S.H.W., Goedert M.
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
Acta Neuropathologica 148(1):60DOI: 10.1007/s00401-024-02807-w
PMID: 39503754
PMCID: PMC11541264
Date of Paper: 06/11/2024
Division: NeurobiologyColussi A., Almeida-Souza L., McMahon H.T.
A single particle analysis method for detecting membrane remodelling and curvature sensing
Journal of Cell Science :jcs.263533DOI: 10.1242/jcs.263533
PMID: 39324332
PMCID: PMC11574359
Date of Paper: 01/11/2024
Division: NeurobiologyWatteyne J., Chudinova A., Ripoll-Sánchez L., Schafer W.R., Beets I.
Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior
Genetics 228(3):iyae141DOI: 10.1093/genetics/iyae141
PMID: 39344922
PMCID: PMC11538413
Date of Paper: 01/11/2024
Division: Neurobiologyde la Rosa-Trevin J.M., Sharov G., Fleischmann S., Morado D., Bollinger J.C., Miller D.J., Terry D.S., Blanchard S.C., Fernandez I.S., Carroni M.
EMhub: a web platform for data management and on-the-fly processing in scientific facilities
Acta crystallographica. Section D, Structural BiologyDOI: 10.1107/S2059798324009471
PMID: 39373194
PMCID:
Date of Paper: 01/11/2024
Division: Facilities (EM)Gong G.Q., Masson G.R., Lee W.J., Dickson J.M.J., Kendall J.D., Rathinaswamy M.K., Buchanan C.M., Middleditch M., Owen B., Spicer J.A., Rewcastle G.W., Denny W.A., Burke J.E., Shepherd P.R., Williams R.L., Flanagan J.U.
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
The Biochemical Journal :BCJ20240479DOI: 10.1042/bcj20240479
PMID: 39485310
PMCID:
Date of Paper: 01/11/2024
Division: Protein & Nucleic Acid ChemistryLou F., Zhou W., Tunc-Ozdemir M., Yang J., Velazhahan V., Tate C.G., Jones A.M.
VPS26 Moonlights as a β-Arrestin-like Adapter for a 7-Transmembrane RGS Protein in Arabidopsis thaliana
BiochemistryDOI: 10.1021/acs.biochem.4c00361
PMID: 39467170
PMCID:
Date of Paper: 28/10/2024
Division: Structural StudiesLeventhal S.S., Bisom T., Clift D., Rao D., Meade-White K., Shaia C., Murray J., Mihalakakos E.A., Hinkley T., Reynolds S.J., Best S.M., Erasmus J.H., James L.C., Feldmann H., Hawman D.W.
Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21
Nature Communications 15(1):9236DOI: 10.1038/s41467-024-53362-7
PMID: 39455551
PMCID: PMC11511847
Date of Paper: 25/10/2024
Division: Protein & Nucleic Acid ChemistryAndrini O., Ben Soussia I., Tardy P., Walker D.S., Peña-Varas C., Ramírez D., Gendrel M., Mercier M., El Mouridi S., Leclercq-Blondel A., González W., Schafer W.R., Jospin M., Boulin T.
Constitutive sodium permeability in a C. elegans two-pore domain potassium channel
Proceedings of the National Academy of Sciences of the United States of America 121(43):e2400650121DOI: 10.1073/pnas.2400650121
PMID: 39405352
PMCID: PMC11513965
Date of Paper: 15/10/2024
Division: NeurobiologyVazquez-Fernandez E., Yang J., Zhang Z., Andreeva A.E., Emsley P., Barford D.
A comparative study of the cryo-EM structures of Saccharomyces cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)
Elife 13:RP100821DOI: 10.7554/elife.100821
PMID: 39401078
PMCID: MC11473103
Date of Paper: 14/10/2024
Division: Structural StudiesManning L.K., Winkenwerder E., Baskind L., Eager K.L.M., Willet C.E., Porebski B., O'Rourke B.A., Tammen I., Gimeno M., Pinczowski P.
A novel missense variant in the <i>RELN</i> gene in sheep with lissencephaly and cerebellar hypoplasia
Veterinary Pathology :3009858241283501DOI: 10.1177/03009858241283501
PMID: 39394905
PMCID:
Date of Paper: 12/10/2024
Division: Protein & Nucleic Acid ChemistryGentile F., Emdin M., Passino C., Montuoro S., Tognini P., Floras J.S., O'Neill J., Giannoni A.
The chronobiology of human heart failure: clinical implications and therapeutic opportunities
Heart Failure ReviewsDOI: 10.1007/s10741-024-10447-1
PMID: 39392534
PMCID:
Date of Paper: 11/10/2024
Division: Cell BiologyShaib A.H., Chouaib A.A., Chowdhury R., Altendorf J., Mihaylov D., Zhang C., Krah D., Imani V., Spencer R.K.W., Georgiev S.V., Mougios N., Monga M., Reshetniak S., Mimoso T., Chen H., Fatehbasharzad P., Crzan D., Saal K.A., Alawieh M.M., Alawar N., Eilts J., Kang J., Soleimani A., Müller M., Pape C., Alvarez L., Trenkwalder C., Mollenhauer B., Outeiro T.F., Köster S., Preobraschenski J., Becherer U., Moser T., Boyden E.S., Aricescu A.R., Sauer M., Opazo F., Rizzoli S.O.
One-step nanoscale expansion microscopy reveals individual protein shapes
Nature BiotechnologyDOI: 10.1038/s41587-024-02431-9
PMID: 39385007
PMCID:
Date of Paper: 09/10/2024
Division: NeurobiologyHochheiser I.V., Geyer M.
Insights into reproduction-regulating NOD-like receptors
Nature Structural & Molecular BiologyDOI: 10.1038/s41594-024-01383-7
PMID: 39333373
PMCID:
Date of Paper: 08/10/2024
Division: Structural StudiesRai S, Szaruga M, Pitera AP, Bertolotti A.
Integrated stress response activator halofuginone protects mice from diabetes-like phenotypes
Journal of Cell Biology Oct 7;223(10):e202405175.DOI: 10.1083/jcb.202405175.
PMID: 39150520
PMCID: PMC11329777
Date of Paper: 07/10/2024
Division: NeurobiologyPospisil D.A., Aragon M.J., Dorkenwald S., Matsliah A., Sterling A.R., Schlegel P., Yu S.C., McKellar C.E., Costa M., Eichler K., Jefferis G.S.X.E., Murthy M., Pillow J.W.
The fly connectome reveals a path to the effectome
Nature 634(8032):201-209DOI: 10.1038/s41586-024-07982-0
PMID: 39358526
PMCID: PMC11446844
Date of Paper: 02/10/2024
Division: NeurobiologyDorkenwald S., Matsliah A., Sterling A.R., Schlegel P., Yu S.C., McKellar C.E., Lin A., Costa M., Eichler K., Yin Y., Silversmith W., Schneider-Mizell C., Jordan C.S., Brittain D., Halageri A., Kuehner K., Ogedengbe O., Morey R., Gager J., Kruk K., Perlman E., Yang R., Deutsch D., Bland D., Sorek M., Lu R., Macrina T., Lee K., Bae J.A., Mu S., Nehoran B., Mitchell E., Popovych S., Wu J., Jia Z., Castro M.A., Kemnitz N., Ih D., Bates A.S., Eckstein N., Funke J., Collman F., Bock D.D., Jefferis G.S.X.E., Seung H.S., Murthy M.; FlyWire Consortium.
Neuronal wiring diagram of an adult brain
Nature 634(8032):124-138DOI: 10.1038/s41586-024-07558-y
PMID: 39358518
PMCID: PMC11446842
Date of Paper: 02/10/2024
Division: NeurobiologySapkal N., Mancini N., Kumar D.S., Spiller N., Murakami K., Vitelli G., Bargeron B., Maier K., Eichler K., Jefferis G.S.X.E., Shiu P.K., Sterne G.R., Bidaye S.S.
Neural circuit mechanisms underlying context-specific halting in Drosophila
Nature 634(8032):191-200DOI: 10.1038/s41586-024-07854-7
PMID: 39358520
PMCID: PMC11446846
Date of Paper: 02/10/2024
Division: NeurobiologyShiu P.K., Sterne G.R., Spiller N., Franconville R., Sandoval A., Zhou J., Simha N., Kang C.H., Yu S., Kim J.S., Dorkenwald S., Matsliah A., Schlegel P., Yu S.C., McKellar C.E., Sterling A., Costa M., Eichler K., Bates A.S., Eckstein N., Funke J., Jefferis G.S.X.E., Murthy M., Bidaye S.S., Hampel S., Seeds A.M., Scott K.
A Drosophila computational brain model reveals sensorimotor processing
Nature 634(8032):210-219DOI: 10.1038/s41586-024-07763-9
PMID: 39358519
PMCID: PMC11446845
Date of Paper: 02/10/2024
Division: NeurobiologySchlegel P., Yin Y., Bates A.S., Dorkenwald S., Eichler K., Brooks P., Han D.S., Gkantia M., Dos Santos M., Munnelly E.J., Badalamente G., Serratosa Capdevila L., Sane V.A., Fragniere A.M.C., Kiassat L., Pleijzier M.W., Stürner T., Tamimi I.F.M., Dunne C.R., Salgarella I., Javier A., Fang S., Perlman E., Kazimiers T., Jagannathan S.R., Matsliah A., Sterling A.R., Yu S.C., McKellar C.E.; FlyWire Consortium; Costa M., Seung H.S., Murthy M., Hartenstein V., Bock D.D., Jefferis G.S.X.E.
Whole-brain annotation and multi-connectome cell typing of Drosophila
Nature 634(8032):139-152DOI: 10.1038/s41586-024-07686-5
PMID: 39358521
PMCID: PMC11446831
Date of Paper: 02/10/2024
Division: NeurobiologyLin A., Yang R., Dorkenwald S., Matsliah A., Sterling A.R., Schlegel P., Yu S.C., McKellar C.E., Costa M., Eichler K., Bates A.S., Eckstein N., Funke J., Jefferis G.S.X.E., Murthy M.
Network statistics of the whole-brain connectome of Drosophila
Nature 634(8032):153-165DOI: 10.1038/s41586-024-07968-y
PMID: 39358527
PMCID: PMC11446825
Date of Paper: 02/10/2024
Division: NeurobiologySu M., Roberts S.J., Sutherland J.D.
RNA-directed peptide synthesis across a nicked loop
Nucleic Acids Research 52(19):11415-11422DOI: 10.1093/nar/gkae702
PMID: 39164017
PMCID: PMC11514466
Date of Paper: 01/10/2024
Division: Protein & Nucleic Acid ChemistrySzeto A.C., Ferreira A.C., McKenzie A.N.
Molecular mechanisms regulating T helper 2 cell differentiation and function
Current Opinion in Immunology 91:102483DOI: 10.1016/j.coi.2024.102483
PMID: 39357077
PMCID:
Date of Paper: 01/10/2024
Division: Protein & Nucleic Acid ChemistryShahbazi M.N., Pasque V.
Early human development and stem cell-based human embryo models
Cell Stem Cell 31(10):1398-1418DOI: 10.1016/j.stem.2024.09.002
PMID: 39366361
PMCID:
Date of Paper: 01/10/2024
Division: Cell BiologyLancaster M.A.
Unraveling mechanisms of human brain evolution
Cell 187(21):5838-5857DOI: 10.1016/j.cell.2024.08.052
PMID: 39423803
PMCID:
Date of Paper: 01/10/2024
Division: Cell BiologyMarshall W., Baum B., Fairhall A., Heisenberg C., Koslover E., Liu A., Mao Y., Mogilner A., Nelson C.M., Paluch E.K., Trepat X., Yap A.
Where physics and biology meet
Current Biology : CB 34(20):R950-R960DOI: 10.1016/j.cub.2024.08.022
PMID: 39437734
PMCID:
Date of Paper: 01/10/2024
Division: Cell Biology
MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.