Peet M. J., Henderson R., Russo C. J.
The energy dependence of contrast and damage in electron cryomicroscopy of biological molecules
Ultramicroscopy 203:125-131. August 2019DOI: 10.1016/j.ultramic.2019.02.007
PMID: 30773415
PMCID:
Date of Paper: 01/08/2019
Division: Structural Studies
Download pdfGattkowski E., Johnsen A., Bauche A., Möckl F., Kulow F., Garcia Alai M., Rutherford T. J., Fliegert R., Tidow H.
Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2
Biochimica et Biophysica Acta. Molecular Cell Research 1866(7):1162-1170. July 2019DOI: 10.1016/j.bbamcr.2018.12.010
PMID: 30584900
PMCID:
Date of Paper: 01/07/2019
Division: Structural StudiesMalcolm J. C., Breuillaud L., Do Carmo S., Hall H., Welikovitch L. A., Macdonald J. A., Goedert M., Cuello A. C.
Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy
Neurobiology of Disease 127:323-338. July 2019DOI: 10.1016/j.nbd.2019.03.018
PMID: 30905766
PMCID:
Date of Paper: 01/07/2019
Division: NeurobiologyLai W. S., Stumpo D. J., Wells M. L., Gruzdev A., Hicks S. N., Nicholson C. O., Yang Z., Faccio R., Webster M. W., Passmore L. A., Blackshear P. J.
Importance of the conserved carboxyl-terminal CNOT1 binding domain to tristetraprolin (TTP) activity in vivo
Molecular and Cellular Biology 39(13). 13 June 2019DOI: 10.1128/MCB.00029-19
PMID: 31036567
PMCID:
Date of Paper: 13/06/2019
Division: Structural StudiesBates A. S., Janssens J., Jefferis G. S., Aerts S.
Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics
Current Opinion in Neurobiology 56:125-134. June 2019DOI: 10.1016/j.conb.2018.12.012
PMID: 30703584
PMCID:
Date of Paper: 01/06/2019
Division: NeurobiologyChitwood P. J., Hegde R. S.
The Role of EMC during Membrane Protein Biogenesis
Trends in Cell Biology 29(5):371-384. May 2019DOI: 10.1016/j.tcb.2019.01.007
PMID: 30826214
PMCID:
Date of Paper: 01/05/2019
Division: Cell BiologyFang X., Wang L., Ishikawa R., Li Y., Fiedler M., Liu F., Calder G., Rowan B., Weigel D., Li P., Dean C.
Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes
Nature 569(7755):265-269. 1 May 2019DOI: 10.1038/s41586-019-1165-8
PMID: 31043738
PMCID:
Date of Paper: 01/05/2019
Division: Protein & Nucleic Acid ChemistryDodonova S. O., Prinz S., Bilanchone V., Sandmeyer S., Briggs J. A. G.
Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses
Proceedings of the National Academy of Sciences of the United States of America 116(20):10048-10057. 29 April 2019DOI: 10.1073/pnas.1900931116
PMID: 31036670
PMCID: PMC6525542
Date of Paper: 29/04/2019
Division: Structural StudiesCrosby P., Hamnett R., Putker M., Hoyle N. P., Reed M., Karam C. J., Maywood E. S., Stangherlin A., Chesham J. E., Hayter E. A., Rosenbrier-Ribeiro L., Newham P., Clevers H., Bechtold D. A., O'Neill J. S.
Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time
Cell 177(4):896-909.e20. 25 April 2019DOI: 10.1016/j.cell.2019.02.017
PMID: 31030999
PMCID: PMC6506277
Date of Paper: 25/04/2019
Division: Cell Biology, Neurobiology
Download pdfCameron G. J. M., Cautivo K. M., Loering S., Jiang S. H., Deshpande A. V., Foster P. S., McKenzie A. N. J., Molofsky A. B., Hansbro P. M., Starkey M. R.
Group 2 innate lymphoid cells are redundant in experimental renal ischemia-reperfusion injury
Frontiers in Immunology 2019; 10: 826. 16 April 2019DOI: 10.3389/fimmu.2019.00826
PMID: 31057549
PMCID: PMC6477147
Date of Paper: 16/04/2019
Division: Protein & Nucleic Acid ChemistryBottermann M., Foss S., Caddy S. L., Clift D., van Tienen L. M., Vaysburd M., Cruickshank J., O'Connell K., Clark J., Mayes K., Higginson K., Lode H. E., McAdam M. B., Sandlie I., Andersen J. T., James L. C.
Complement C4 Prevents Viral Infection through Capsid Inactivation
Cell Host & Microbe 25(4):617-629.e7. 10 April 2019DOI: 10.1016/j.chom.2019.02.016
PMID: 30926239
PMCID:
Date of Paper: 10/04/2019
Division: Protein & Nucleic Acid Chemistry
Download pdfKerscher B., Barlow J. L., Rana B. M., Jolin H. E., Gogoi M., Bartholomew M. A., Jhamb D., Pandey A., Tough D. F., van Oosterhout A. J. M., McKenzie A. N. J.
BET bromodomain inhibitor iBET151 impedes human ILC2 activation and prevents experimental allergic lung inflammation
Frontiers in Immunology 10:678. 9 April 2019DOI: 10.3389/fimmu.2019.00678
PMID: 31024538
PMCID: PMC6465521
Date of Paper: 09/04/2019
Division: Protein & Nucleic Acid ChemistryMohiuddin M., Rahman M. M., Sale J. E., Pearson C. E.
CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs
Nucleic Acids Research 47(6):2966-2980. 8 April 2019DOI: 10.1093/nar/gkz009
PMID: 30657944
PMCID: PMC6451104
Date of Paper: 08/04/2019
Division: Protein & Nucleic Acid Chemistry
Download pdfAnderson A., Chew Y. L., Schafer W., McMullan R.
Identification of a conserved, orphan G-protein coupled receptor required for efficient pathogen clearance in C. elegans
Infection and Immunity 87(4). April 2019DOI: 10.1128/IAI.00034-19
PMID: 30692178
PMCID:
Date of Paper: 01/04/2019
Division: NeurobiologyLiu Z., Ajram G., Rossi J. C., Pascal R.
The Chemical Likelihood of Ribonucleotide-α-Amino acid Copolymers as Players for Early Stages of Evolution
Journal of Molecular Evolution 87(2-3):83-92. April 2019DOI: 10.1007/s00239-019-9887-7
PMID: 30788531
PMCID: PMC6443614
Date of Paper: 01/04/2019
Division: Protein & Nucleic Acid Chemistry
Download pdfGangadhara G., Dahl G., Bohnacker T., Rae R., Gunnarsson J., Blaho S., Öster L., Lindmark H., Karabelas K., Pemberton N., Tyrchan C., Mogemark M., Wymann M. P., Williams R. L., Perry M. W. D., Papavoine T., Petersen J.
A class of highly selective inhibitors bind to an active state of PI3Kγ
Nature Chemical Biology 15(4):348-357. April 2019DOI: 10.1038/s41589-018-0215-0
PMID: 30718815
PMCID:
Date of Paper: 01/04/2019
Division: Protein & Nucleic Acid ChemistryBeale A. D., Kruchek E., Kitcatt S. J., Henslee E. A., Parry J. S. W., Braun G., Jabr R., von Schantz M., O'Neill J. S., Labeed F. H.
Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells
Journal of Biological Rhythms 34(2):144-153. April 2019DOI: 10.1177/0748730419836370
PMID: 30898060
PMCID:
Date of Paper: 01/04/2019
Division: Cell BiologyGiandomenico S. L., Mierau S. B., Gibbons G. M., Wenger L. M. D., Masullo L., Sit T., Sutcliffe M., Boulanger J., Tripodi M., Derivery E., Paulsen O., Lakatos A., Lancaster M. A.
Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output
Nature Neuroscience 22(4):669-679. April 2019DOI: 10.1038/s41593-019-0350-2
PMID: 30886407
PMCID:
Date of Paper: 01/04/2019
Division: Cell Biology, NeurobiologyAspuru-Guzik A., Baik M. H., Balasubramanian S., Banerjee R., Bart S., Borduas-Dedekind N., Chang S., Chen P., Corminboeuf C., Coudert F. X., Cronin L., Crudden C., Cuk T., Doyle A. G., Fan C., Feng X., Freedman D., Furukawa S., Ghosh S., Glorius F., Jeffries-El M., Katsonis N., Li A., Linse S. S., Marchesan S., Maulide N., Milo A., Narayan A. R. H., Naumov P., Nevado C., Nyokong T., Palacin ., Reid M., Robinson C., Robinson G., Sarpong R., Schindler C., Schlau-Cohen G. S., Schmidt T. W., Sessoli R., Shao-Horn Y., Sleiman H., Sutherland J., Taylor A., Tezcan A., Tortosa M., Walsh A., Watson A. J. B., Weckhuysen B. M., Weiss E., Wilson D., Yam V. W., Yang X., Ying J. Y., Yoon T., You S. L., Zarbin A. J. G ., Zhang H.
Charting a course for chemistry
Nature Chemistry 11(4):286-294. April 2019DOI: 10.1038/s41557-019-0236-7
PMID: 30903035
PMCID:
Date of Paper: 01/04/2019
Division: Protein & Nucleic Acid ChemistryGersch M., Wagstaff J. L., Toms A. V., Graves B., Freund S. M. V., Komander D.
Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity
Molecular Cell e-pub: published online 26 March 2019DOI: 10.1016/j.molcel.2019.02.030
PMID: 30926242
PMCID:
Date of Paper: 26/03/2019
Division: Protein & Nucleic Acid Chemistry
Download pdfHill C. H., Boreikaitė V., Kumar A., Casañal A., Kubík P., Degliesposti G., Maslen S., Mariani A., von Loeffelholz O., Girbig M., Skehel M, Passmore L. A.
Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex
Molecular Cell 73(6):1217-1231.e11. 21 March 2019DOI: 10.1016/j.molcel.2018.12.023
PMID: 30737185
PMCID: PMC6436931
Date of Paper: 21/03/2019
Division: Structural Studies
Download pdfFalcon B., Zivanov J., Zhang W., Murzin A. G., Garringer H. J., Vidal R., Crowther R. A., Newell K. L., Ghetti B., Goedert M., Scheres S. H. W.
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
Nature e-pub: published online 20 March 2019DOI: 10.1038/s41586-019-1026-5
PMID: 30894745
PMCID:
Date of Paper: 20/03/2019
Division: Neurobiology, Structural StudiesColin-York H., Javanmardi Y., Skamrahl M., Kumari S., Chang V. T., Khuon S., Taylor A., Chew T. L., Betzig E., Moeendarbary E., Cerundolo V., Eggeling C., Fritzsche M..
Cytoskeletal Control of Antigen-Dependent T Cell Activation
Cell Reports 26(12):3369-3379.e5. 19 March 2019DOI: 10.1016/j.celrep.2019.02.074
PMID: 30893608
PMCID: PMC6426652
Date of Paper: 19/03/2019
Division: Neurobiology
Download pdfShapson-Coe A., Valeiras B., Wall C., Rada C.
Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex
PloS one 14(3):e0213553. 19 March 2019DOI: 10.1371/journal.pone.0213553
PMID: 30889214
PMCID: PMC6424451
Date of Paper: 19/03/2019
Division: Protein & Nucleic Acid Chemistry
Download pdfGoedert M., Falcon B., Zhang W., Ghetti B., Scheres S. H. W.
Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases
Cold Spring Harbor Symposia on Quantitative Biology e-pub: published online 18 March 2019DOI: 10.1101/sqb.2018.83.037580
PMID: 30886056
PMCID:
Date of Paper: 18/03/2019
Division: Neurobiology, Structural Studies