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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Image365

LMB 365 – Day 305

Published on 1 November, 2019

This photo for day 305 of #LMB365 shows our Deputy Head of Scientific Computing, Toby Darling, loading GPU servers into racks in the new server room. The LMB’s computing cluster has 4,108 CPU cores, 128 GPU cards and access to over 5PB of storage.

LMB 365 – Day 304

Published on 31 October, 2019

Day 304 of #LMB365 shows a model of the 70S ribosome, printed by Mark Hoelzer at 3D Molecular Designs. The atomic co-ordinates were provided by Venki Ramakrishnan, who shared the 2009 Nobel Prize in Chemistry with Thomas Steitz and Ada Yonath for their work on the ribosome.

LMB 365 – Day 303

Published on 30 October, 2019

Day 303 of #LMB365 is a photograph from Madeline Lancaster’s group in the Cell Biology Division of brain organoids bathing in a nutrient rich broth that helps them to grow and develop. Their large size means you can see them with your bare eye.

LMB 365 – Day 302

Published on 29 October, 2019

Day 302 of #LMB365 shows the LMB Governing Board in 1967: Hugh Huxley, John Kendrew, Max Perutz, Francis Crick, Fred Sanger and Sydney Brenner. When the LMB was formally set-up in 1962, out of the previous MRC Unit, Max was appointed Chairman of a Governing Board, rather than being Director. The board met only occasionally when major decisions of scientific policy were needed but they did not direct the Lab’s research, just provided the means by which people could carry out their work. The Governing Board was the fore-runner of the current Executive Committee, which is chaired by the LMB Director

LMB 365 – Day 301

Published on 28 October, 2019

Day 301 of #LMB365 shows the sun setting on the west end of the LMB building. It’s amazing how the building can look at different times of day throughout the year.

LMB 365 – Day 300

Published on 27 October, 2019

CryoEM structures determined by Yorgo Modis’ group show how the innate immune sensor MDA5 recognizes viral RNA by forming filaments. ATP hydrolysis is coupled to structural changes in the filament, which are proposed to promote discrimination between viral and cellular RNAs. Depicted here on day 300 of #LMB365 is a model of an MDA5-dsRNA filament (foreground). A viral dsRNA genome and the endosome that delivered it into the cytosol are shown in the background.

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