This image provided by David Barford for day 317 of #LMB365 shows the cryo-EM structure of the anaphase-promoting complex (APC/C) (surface representation) bound to its inhibitor, the mitotic checkpoint complex (MCC) (ribbons representation). The MCC exerts the spindle assembly checkpoint during mitosis to coordinate APC/C activity with the correct attachment of all chromosomes to the mitotic spindle. This ensures faithful chromosome segregation and prevents aneuploidy, a causative factor in cancer and congenital defects.
Image365
LMB 365 – Day 316
Fire safety is vitally important for the protection of our staff and facilities. This photo for day 316 of #LMB365 shows a recent hands-on staff training session on how, when and where to use fire extinguishers.
LMB 365 – Day 315
On day 315 of #LMB365 we see the PDB Art Exhibition, currently on display in the LMB’s atrium, in which students from local schools have produced amazing works of art inspired by protein structures. More close-ups to come…
LMB 365 – Day 314
It’s not every day a steam train goes past the LMB. Day 314 of #LMB365 shows the 61306 Mayflower on a recent trip from London. Mayflower is a B1 Class locomotive and was built in 1948 by the North British Locomotive Company in Glasgow for the London & North Eastern Railway
LMB 365 – Day 313
The image for day 313 of #LMB365 shows apical localisation of thehmRNA (magenta) in the fruit fly embryo. This mRNA is trafficked by the microtubule motor dynein and Simon Bullock’s group in Cell Biology has used this system to shed light on how dynein recognises cargoes and how its motility is regulated. Blue and green signals are from DNA and nuclear envelopes, respectively.
LMB 365 – Day 312
LMB staff have spotted a variety of small creatures when wandering around outside the LMB building and on the wider Campus as seen here on day 312 of #LMB365.