The Electronics Workshop at the LMB designs many items of custom equipment to facilitate the scientific research. Their Computer Aided Design & Manufacturing (CADCAM) systems are invaluable in providing swift and accurate development, none more so than the printed circuit board production machine, featured here on day 239 of #LMB365, which allows them to make complex circuit designs in a matter of hours.
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LMB 365 – Day 238
Day 238 of #LMB365 shows a cerebral organoid ventricle labelled with markers of neuroepithelial cells, neuronal progenitors and neurons from Laura Pellegrini in Madeline Lancaster’s group in Cell Biology. The complex structural organisation of these cells and how they position within the tissue highly resembles early stages of brain development.
LMB 365 – Day 237
On day 237 of #LMB365 is a model of the structure of the enzyme, F1-ATPase. The structure was first published one this day in 1994 in a landmark paper in Nature. F1-ATPase is the catalytic component of ATP synthase, the enzyme responsible for the synthesis of ATP in living cells. The gamma subunit (blue) is believed to rotate within the three alpha (red) and three beta (yellow) subunits during catalysis. For his work in solving this structure John Walker shared the 1997 Nobel Prize in Chemistry. Jan Pieter Abrahams, Andrew G. W. Leslie, René Lutter; John E. Walker. Structure at 2.8 angstrom resolution of F1-ATPase from bovine heart mitochondria. Nature 370: 621-628, 1994
LMB 365 – Day 236
Day 236 of #LMB365,taken by Neil Grant in the LMB’s Visual Aids team, shows the geometric patterns and reflections that can be seen when exploring the exterior of the LMB building on a sunny day.
LMB 365 – Day 235
On day 235 of #LMB365 PhD student Ross Hill celebrates with fellow students and postdocs the publication of his first paper from his PhD. The culmination of 3½ years of work and the ultimate accolade: to see your work reaching the scientific community. Worth a toast! Read more at https://t.co/G8ylgimczZ?amp=1
LMB 365 – Day 234
Amoebae and some cancer cells can feed by swallowing large gulps of their surrounding medium. An amoeba can drink nearly its own volume in an hour – an amazing feat if scaled to humans. This process is known as macropinocytosis, and has been studied by Rob Kay’s group in the Cell Biology Division. Day 234 of #LMB365 shows cells forming cups from their plasma membrane. These are shaped around a patch of the lipid PIP3 (orange), surrounded by a necklace of the SCAR/WAVE protein (green) that guides formation of the walls of the cup