On day 197 of #LMB365 we have a picture by Katja Röper in the Cell Biology Division. This image shows a confocal section of the primordium of the salivary glands in a Drosophila embryo, a model system for the formation of tubular organs. The Röper lab studies how important tubular organs from flies to humans form during development. The image is false-coloured with cell outlines labelled blue.
Image365
LMB 365 – Day 196
This shot of the LMB for day 196 of #LMB365 was taken by Oleksiy Kovtun. It was taken from Hobson’s Park at Great Kneighton and you can see the top of a train travelling between London and Cambridge past the building
LMB 365 – Day 195
Cricket was the first recreational activity organised at the LMB. The LMB cricket team officially began playing in the interdepartmental league in 1969 under the chairmanship of Max Perutz and this year marks the team’s golden jubilee! Notable past players include Fred Sanger and John Walker. This image for day 195 of #LMB365 shows the current team who are still actively competing in the interdepartmental cricket league, which itself celebrated its 85th anniversary in 2018.
LMB 365 – Day 194
This photo for day 194 of #LMB365 shows an engineer cutting into the existing chilled water circuit for the new server room. The welder’s left hand is on a pipe that has been frozen with liquid nitrogen to freeze the water within and enable it to be worked on “live”.
LMB 365 – Day 193
This image for day 193 of #LMB365 is provided by Jonathan Ribeiro in Gerry Crossan’s lab in the PNAC division. The Crossan lab studies how germ cells faithfully transmit genetic information from parent to offspring. Before becoming spermatozoa (sperm) or oocytes (eggs), germ cells undergo a sequence of cellular events including meiosis. During meiosis, germ cells switch from having two copies of the genome to having only one copy. This division of the genome is essential for the later fusion of a spermatozoon and an oocyte, or fertilisation, in order to produce a new individual with a normal chromosome count. This image is a snapshot of meiosis when chromosomes are preparing to segregate. Chromosomes are labelled in green and blue and sex chromosomes (that determine if the new individual is male or female) have a supplementary stain, in red.
LMB 365 – Day 192
Liz Miller’s lab in Cell Biology uses yeast colony arrays, seen here on day 192 of #LMB365, to test growth of >5000 genetic mutants all at once. They pin the yeast cells at 384 density to capture the full genome on only 15 plates and quantify colony size to measure growth defects. Using such high throughput screening, Liz’s lab aims to identify new players in protein quality control in the secretory pathway.