Day 341 of #LMB365 is a 3D printed model of a cerebral organoid, made by the LMB’s Technical Instrumentation Workshop. Madeline Lancaster’s lab in Cell Biology uses this for public outreach to help illustrate what brain organoids look like inside and out.
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LMB 365 – Day 340
Simon Bullock’s lab uses a combination of in vitro and in vivo methods to investigate how microtubule-based cargo transport is orchestrated in cells. On day 340 of #LMB365 Simon illustrates this approach by overlaying a crystal structure from a motor adaptor, which was solved by his group, on an image of a symmetric ‘two-tailed’ fly embryo that has a mutation in this protein.
LMB 365 – Day 339
Day 339 of #LMB365 shows dedicated members of the Domestic Services team working hard one recent weekend preparing the LMB’s restaurant floor for the annual application of a new polish.
LMB 365 – Day 338
Christmas has come to the LMB and for day 338 of #LMB365 Rihab Gam has taken this lovely photo of the Christmas tree now brightening up the LMB’s reception area.
LMB 365 – Day 337
Day 337 of #LMB365 shows this year’s PhD student photo featuring most of the current students, together with the LMB Director, Director of Studies, Postgraduate Administrator and Assistant. The LMB students are a diverse group and come from over 25 countries across the world. Look back at day 261 to see the photo being taken…
LMB 365 – Day 336
On day 336 of #LMB365 we recognise Michel Goedert, who started work at the LMB 35 years ago. As a postdoctoral fellow, he spent much of his time learning the rudiments of molecular biology and applying them to the study of Alzheimer’s disease. He became a programme leader in 1988 and has been involved in the work on the molecular nature of the paired helical and straight filaments of Alzheimer’s disease, which showed that tau protein is an integral component of these filaments. This established the concept that the aggregation of tau protein is sufficient to cause neurodegeneration and dementia. Further work showed that the protein alpha-synuclein is the major component of the Lewy pathology, the defining neuropathological characteristic of Parkinson’s disease and dementia with Lewy bodies, and of the filamentous inclusions of multiple system atrophy, a related movement disorder. In recent collaborative work, it was discovered that aggregated human tau proteins exhibit prion-like properties and can exist as distinct conformers. Michel was Head/joint head of the Neurobiology Division from 2003-2016