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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

How the fate of immune cell precursors is decided

Published on 11 January, 2021

Type 2 ILCs (ILC2s) play an important role in dealing with parasites and are implicated in allergy. Andrew McKenzie’s group has discovered that the transcription factor RORα acts as a checkpoint controlling divergence between T cell and ILC2 development.

A new 2D protein material for studying receptor endocytosis

Published on 6 January, 2021

Emmanuel Derivery’s group, in collaboration with David Baker’s group in Seattle, have, for the first time, re-engineered two proteins so that they assemble into a 2D material and used this design to investigate a fundamental process of cell biology, receptor endocytosis.

TRIM21 links antibody and T cell immunity to combat viral infection

Published on 4 December, 2020

Our immune system generates a strong antibody response against nucleoproteins, but the role of this has not been understood. Leo James’ group has revealed a new mechanism that could have important implications for SARS-CoV-2 vaccination and treatment.

First structure of a fungal GPCR

Published on 2 December, 2020

Human GPCRs are the targets of approximately 34% of all FDA-approved drugs. GPCRs in fungi could also be useful drug targets, but no structures of fungal GPCRs had been solved. Chris Tate’s group has now determined the first structure of a fungal GPCR.

Ribosomal rescue in our mitochondria

Published on 27 November, 2020

Mitochondrial ribosomes are different from those in the cytoplasm of human cells and little is known about their quality control. Venki Ramakrishnan’s group has discovered a novel pathway to rescue stalled mitoribosomes and determined structures of the rescue factors.

A connection between stress detection and lifestyle decisions in worms

Published on 24 November, 2020

Rebecca Taylor’s group has identified a signalling molecule that connects detection of a stressful environment by the nervous system with molecular defence mechanisms in other tissues and leads to changes in feeding behaviour and reproduction.

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