Producing maps of how neurons connect with each other (connectomes) allows scientists to build and test theories of brain function. Greg Jefferis’ group have presented the first full map of olfactory, thermosensory, and hygrosensory projection neurons in the fly brain.
Insight on Research
A new directed evolution technique to unlock the potential of XNAs
Use of reverse transcription for synthesis of xeno-nucleic acids is limited by low reverse transcriptase enzyme activity. Philipp Holliger’s group have developed a new directed evolution method to improve reverse transcriptase activity for any nucleic acid chemistry.
How cells avoid and resolve ribosome traffic jams
Multiple ribosomes speed along an mRNA to translate the genetic code into proteins. Szymon Juszkiewicz and Manu Hegde now find that when ribosomes collide, cells stop new ribosomes from starting translation and recruit a factor that clears the collision.
First complete atomic model of condensin lays foundation for understanding chromosome compaction
Each of our cells contains about two metres of DNA. To be able to store all of this, the DNA must be very tightly compacted. Jan Löwe’s group have produced the first atomic model of condensin, a complex known to have a role in compacting DNA into chromosomes, in its entirety.
Balancing an appropriate immune response in the gut
Menna Clatworthy’s group has identified a key signalling molecule in determining the balance between wound healing and defence against bacterial invasion, with implications for our understanding of the immune system’s role in inflammatory bowel disease.
A cellular pacemaker in the central body clock
Our daily cycle is controlled by a central clock known as the SCN, but it has been unclear how the network of cells that make up the SCN generate the properties that make it a strong clock. Michael Hastings’ group has identified a signalling axis that acts as a pacemaking hub.