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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

Discovery of a chaperone for membrane proteins

Published on 19 August, 2020

Proteins embedded in the cellular membrane perform a wide variety of necessary tasks. Most are folded into complex shapes that pass back and forth across the membrane. Patrick Chitwood and Manu Hegde have discovered a new type of chaperone that helps them assemble correctly.

Studying the spike protein of SARS-CoV-2

Published on 18 August, 2020

John Briggs’ group has led two new studies of the spike (S) protein that mediates binding to the receptor ACE2 and is the dominant target of the immune system, with applications for development of vaccines and diagnostic tests.

Membrane characteristics tune enzyme activity

Published on 4 August, 2020

Lipid membranes surround our cells and form the boundaries around compartments within them. Roger Williams’ group has now shown how membrane characteristics can tune the activities of protein complexes with important roles in autophagy and endosomal membrane trafficking.

A map to show the way to sense smell, temperature, and humidity

Published on 23 July, 2020

Producing maps of how neurons connect with each other (connectomes) allows scientists to build and test theories of brain function. Greg Jefferis’ group have presented the first full map of olfactory, thermosensory, and hygrosensory projection neurons in the fly brain.

A new directed evolution technique to unlock the potential of XNAs

Published on 20 July, 2020

Use of reverse transcription for synthesis of xeno-nucleic acids is limited by low reverse transcriptase enzyme activity. Philipp Holliger’s group have developed a new directed evolution method to improve reverse transcriptase activity for any nucleic acid chemistry.

How cells avoid and resolve ribosome traffic jams

Published on 16 July, 2020

Multiple ribosomes speed along an mRNA to translate the genetic code into proteins. Szymon Juszkiewicz and Manu Hegde now find that when ribosomes collide, cells stop new ribosomes from starting translation and recruit a factor that clears the collision.

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