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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

High-resolution structure of a GPCR-arrestin complex

Published on 17 June, 2020

Understanding minute structural differences in (G protein-coupled receptor) GPCR complexes could lead to the design of more efficacious drugs that have fewer side effects

Cell-invading bacteria are converted into signalling platforms that may trigger septic shock

Published on 15 June, 2020

Septic shock is a common cause of death that can be triggered by LPS, a component of the outer membrane of some bacteria. Felix Randow’s group has shown how the immune response against cytosol-invading bacteria is activated by a signalling platform built on their surface.

Brain organoids with the potential to predict drug permeability

Published on 12 June, 2020

The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides various nutrients. Madeline Lancaster’s group have now developed a new brain organoid that produces CSF and has the potential to predict whether drugs can access the brain.

Primitive genetic alphabet based on RNA and DNA

Published on 3 June, 2020

New research suggests that DNA building blocks may have coexisted with RNA at the dawn of life

First structures of α-synuclein filaments from human brain

Published on 28 May, 2020

Abnormal filaments of α-synuclein define several neurodegenerative diseases, including multiple system atrophy (MSA) and Parkinson’s disease. Michel Goedert’s and Sjors Scheres’ groups have now determined the first structures of α-synuclein filaments from human brain.

Tracing a transcription initiation factor’s molecular journey across evolutionary timescale

Published on 13 May, 2020

M Madan Babu’s group publishes a comprehensive model for the functional innovations of TBP.

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