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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > Writing the LINE-1s: How does LINE-1 remodel human DNA to insert its sequence throughout the genome?

Writing the LINE-1s: How does LINE-1 remodel human DNA to insert its sequence throughout the genome?

Writing the LINE-1s: How does LINE-1 remodel human DNA to insert its sequence throughout the genome?

Published on 7 March, 2025

Spearheaded by postdoc George Ghanim, Kelly Nguyen’s group in the LMB’s Structural Studies Division have investigated the molecular mechanisms which allow LINE-1 to propagate throughout the genome via retrotransposition during target-primed reverse transcription.

The moment Max Perutz discovered the structure of haemoglobin

Published on 6 March, 2025

The History Hour by BBC World Service have covered Max Perutz’s Nobel Prize winning work to determine the structure of haemoglobin. Their coverage includes archival interviews with Max himself, plus contributions from Alan Fersht, emeritus scientist in the LMB’s PNAC Division and a contemporary of Max’s. More…

Sortera Bio spins out of the LMB to pioneer new frontiers in biologics discovery

Published on 21 February, 2025

New UK-based biotechnology company launched to realise therapeutic potential of Deep Screening technology developed by Ben Porebski and Philipp Holliger at the LMB.

Kelly Nguyen: Cell scientist to watch

Published on 14 February, 2025

Kelly Nguyen, Group Leader in the LMB’s Structural Studies Division, speaks to the Journal of Cell Science on several topics, including the inspirations behind her career so far, the value of mentorship, and her passion for martial arts. More…

Shankar Balasubramanian to deliver 2025 Francis Crick Lecture

Published on 12 February, 2025

The 2025 Francis Crick Lecture titled ‘The DNA Quadruplex Helix’ will be given by Shankar Balasubramanian at 11am on Wednesday 19th February.

Asgard archaea proteins reveal evolutionary secrets of membrane remodelling

Published on 11 February, 2025

Studying Asgard archaea, Buzz Baum’s group in the LMB’s Cell Biology Division and Aurelien Roux’s group at the University of Geneva, provide insights into the earliest origins of ESCRT-III and reveal how its proteins work together to remodel membranes.

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