A piece in Alzforum highlights two new therapeutics that degrade tau aggregates and improve symptoms of neurodegeneration in mice. The technology has been developed by Leo James’ group, in the LMB’s PNAC Division, and Will McEwan’s group at the UK Dementia Research Institute at the University of Cambridge. More…
Targeting Intracellular Tau Aggregates for Destruction
Silvia Arber to deliver 2024 Crick Lecture
The 2024 Francis Crick Lecture titled ‘Neuronal circuits for body movements’ will be given by Silvia Arber at 11am (BST) on Monday 30th September.
Using ultrasound to determine pregnancy in mice
Introduction of ultrasound machines has allowed LMB animal technicians to accurately detect pregnancy in mice as early as 5.5 days, which ultimately reduces the number of mice needed for research.
Wesley Sundquist awarded 2024 Horwitz Prize together with Scott Emr for discovering the ESCRT pathway
LMB 1988 – 1992, Scientific Visitor, Postdoctoral Fellow, Structural Studies Congratulations to Wesley Sundquist, awarded the 2024 Louisa Gross Horwitz Prize together with Scott Emr for discovering the ESCRT (Endosomal Sorting Complexes Required for Transport) pathway and revealing how it works. Wes and colleagues discovered how and why ESCRT complexes are required for HIV replication […]
The LMB welcomes new Group Leader Joergen Kornfeld
Joergen Kornfeld’s group in the LMB’s Neurobiology Division will investigate the connectomics of learned behaviour using the zebra finch as a model.
New potential therapy for neurodegeneration removes tau aggregates and improves motor function
Leo James’ group, in the LMB’s PNAC Division, have worked with Will McEwan’s group at the UK Dementia Research Institute to design two new therapeutics which harnesses cellular machinery to remove tau aggregates, improving motor skills in mice affected by neurodegenerative disease.