The LMB’s Madeline Lancaster spoke to the Journal of the American Medical Association (JAMA) about her work on brain organoids and their potential future uses. More…
For difficult-to-model brain diseases, brain organoids come to the rescue
Aaron Klug (1926 – 2018)
Aaron Klug, Director of the LMB from 1986 to 1996, President of The Royal Society from 1995 to 2000 and 1982 Nobel Laureate, died on Tuesday 20th November 2018. Aaron was instrumental in revealing the structures of complex biological molecules, from viruses to tRNA, to chromatin and zinc fingers. His most important contribution to scientific research […]
Daniel McGillivray Brown. 3 February 1923-24 April 2012
Dan Brown was a nucleic acids chemist of the highest order, beginning with pioneering work under Lord Alexander Todd in the 1950s at University of Cambridge on chemical methods for synthesis of nucleosides and nucleotides. In 1982 he moved to the LMB and developed a method to prepare single-stranded DNA probes for detection of RNA […]
How replication of DNA is initiated at origins
We each replicate billions of metres of DNA every hour in our dividing cells and it is important that this DNA is replicated accurately. This requires a complex set of machinery called the replisome to unwind the paired strands of DNA allowing different polymerase enzymes to produce new copies. DNA replication is further complicated by […]
New insight into how membrane proteins are made
The human genome encodes thousands of proteins that are embedded in the membranes of all cells. These membrane proteins have numerous functions ranging from ion transport, to cell communication, to sensing odours, and others. In order to carry out these functions, they must be precisely oriented, folded, and assembled correctly. New research from Manu Hegde’s […]
Decades of discovery set to revolutionise healthcare
A summary of key milestones that show how discovery science has been translated into a novel technology set to revolutionise healthcare. The milestones include work at the LMB on the structure of DNA and development of DNA sequencing. More…