Many complex tubular organs, including kidney, lung, the intestine and several glands, form from a flat layer of cells during animal development. Failure of proper tube formation underlies severe congenital malformations such as Spina Bifida, and the failure to maintain tube architecture for instance underlies Polycystic Kidney Diseases. How tissues transition from flat 2D structures […]
How flat sheets of cells become tubular organs: observing cellular dynamics from 2D to 3D
Scientists identify exoplanets where life could develop as it did on Earth
Scientists have identified planets outside our solar system where the same chemical conditions exist that may have led to life on Earth. The researchers, from John Sutherland’s group in the LMB’s PNAC Division and the University of Cambridge Cavendish Laboratory, found that the chances for life to develop on the surface of a rocky planet […]
Complete fly brain images at nanoscale resolution
A neuroscience milestone: a high-resolution digital snapshot of the adult fruit fly brain. Researchers can now trace the path of any one neuron to any other neuron throughout the whole brain. The research, lead by a team of scientists at the Howard Hughes Medical Institute’s Janelia Research Campus, required the collaboration of dozens of other […]
Making the undruggable druggable: the first platform to discover selective phosphatase inhibitors
Anne Bertolotti’s group in the LMB’s Neurobiology Division have developed the first platform to discover selective inhibitors of phosphatases, a class of enzyme which have largely been considered ‘undruggable’. This has allowed Anne’s group to identify a small molecule, Raphin1, which selectively inhibits a protein phosphatase and is effective in a mouse model of Huntington’s […]
Two new group leaders at the LMB: Chris Russo and Gerry Crossan
The LMB is delighted to announce that Chris Russo and Gerry Crossan have progressed from Independent Investigator Scientist positions to become Group Leaders at the LMB. Chris and Gerry join more than fifty-five group leaders at the LMB, representing a diverse range of science and recruited from around the world. Chris Russo Chris will be […]
Greg Jefferis awarded Francis Crick Medal and Lecture by the Royal Society
Greg Jefferis, group leader in the LMB’s Neurobiology Division, has been awarded the Francis Crick Medal and Lecture 2019 in recognition of his discoveries concerning the developmental and functional logic of sensory information processing. The human brain is arguably the most complex structure in our universe. Understanding how its 100 billion nerve cells control our […]