Lori Passmore and her group have used electron cryo-microscopy to solve the structure of CPF, a protein complex critical for gene expression. Understanding the structure and function of intact CPF, and how it is assembled, has been a central question in the field of gene expression for decades. [A Log-in or subscription may be required […]
Using cryo-EM to solve the structure of a protein complex critical for gene expression
PINK1 caught on the brink of phosphorylation
Scientists have caught a rare view of an unusual kinase poised to phosphorylate its substrate. Led by David Komander, MRC Laboratory of Molecular Biology in Cambridge, England, U.K., the researchers reported the crystal structure of the kinase PINK1 bound to ubiquitin in the October 30 Nature. “We captured a pre-catalytic state, a snapshot of PINK1 […]
LMB cycles to first place in September Challenge
LMB cyclists have ridden to the top of the leader board in this year’s Cycle September Challenge, a fun, free National competition, organised by Love to Ride, to see which workplaces can get the most people riding. During the month-long challenge, 179 members of the LMB collectively cycled on 3,677 occasions covering a distance of […]
New insights into ubiquitin phosphorylation and the development of early-onset Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative condition caused by the loss of dopaminergic neurons in the midbrain, which manifests clinically in the form of characteristic motor defects. Most PD cases are sporadic and found in people above the age of 60. However, roughly 10% of PD cases are autosomal recessive juvenile forms (AR-JP), causing early-onset […]
The missing link between golgins and endosomal vesicles discovered
Inside our cells there are many distinct membrane compartments – organelles – which carry out the different tasks that allow the cell to function. Each organelle is like a factory that requires a constant supply of raw materials to stay active. Small transport vesicles deliver this cargo of particular proteins and lipids to each organelle. […]
Macmillan coffee morning at LMB raises £375
The LMB’s HR team, supported by colleagues at the LMB, once again took part in the World’s Biggest Coffee Morning in aid of Macmillan Cancer Support. For the third year in a row, the LMB showcased their baking skills and donated a generous amount of sweet and savoury snacks for everyone to enjoy. This year […]