MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Uncovering the action of a selective holophosphatase inhibitor

Uncovering the action of a selective holophosphatase inhibitor

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Proteins can be reversibly phosphorylated – phosphate groups are added to proteins by the action of kinase enzymes and can be removed by phosphatases. This controls a huge variety of cellular processes and targeting phosphorylation thus offers a board range of therapeutic opportunities. Indeed, kinases have received much attention in pharmaceutical research, yet phosphatases have […]

Reprogramming gene expression with small molecules

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When cells divide, they must accurately copy their genetic material (DNA) and also ensure that their pattern of gene expression is maintained – genes that were ‘on’ before the cell divides need to remain on in the daughter cell, and genes that were ‘off’ need to remain off. These patterns of gene expression are determined […]

LMB alumni return to share their career experiences

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The LMB and Cambridge AWiSE recently held their 11th annual “What Next For Your Career in Science?” event in the LMB’s Max Perutz Lecture Theatre. The three speakers, Monika Papworth, Elizabeth Fairley and Sarah Cumbers, were all LMB alumni, who since leaving the LMB have gone on to be successful in diverse areas.  All of […]

Artistic flair on show at the LMB

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LMB staff shared their artistic flair during the annual LMB Art Show, with exhibits including hand-made jewellery, paintings, photographs, cross stitch and crafts on display in the LMB atrium for all to see and enjoy for two weeks in July. A wide range of creativity was on show from the 22 exhibitors who took part […]

Tau filaments from the Alzheimer’s brain revealed

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Tau filaments isolated from an Alzheimer’s brain are the latest, high-profile exploit of cryo-electron microscopy. Crafting a technique that has become his claim to fame, Sjors Scheres of the MRC Laboratory of Molecular Biology in Cambridge, England, teamed up with Michel Goedert, also at MRC, to solve 3.4-Angstrom resolution structures of both straight and paired […]