New research from Anne Bertolotti’s group in the LMB’s Neurobiology Division reveals that nanomolar ATP-competitive inhibitors of integrated stress response (ISR) kinases unexpectedly activate the ISR at micromolar concentrations by directly binding to and activating a sister ISR kinase.
Activation of the integrated stress response by inhibitors of its kinases
The LMB welcomes Juliette Fedry as a new Group Leader
Juliette Fedry’s research group in the LMB’s Cell Biology Division will aim to reveal how proteostasis is organized normal health and how it goes awry during diseases.
Andrew McLachlan. 25 January 1935 – 8 July 2022
LMB 1967-2006, Group Leader, MRC Retired Worker, Structural Studies After switching scientific disciplines from theoretical chemistry to molecular biology, Andrew McLachlan arrived at the LMB in 1967, where he remained a key member of the Structural Studies Division until 2006. Notably, he developed methods for aligning the sequences of different proteins, and, in collaboration with […]
Madeline Lancaster awarded the Cheryll Tickle Medal from the British Society for Developmental Biology
Madeline Lancaster, Group Leader in the LMB’s Cell Biology Division, has been announced as the 2023 recipient of the Cheryll Tickle Medal from the British Society for Developmental Biology.
Herman Waldmann awarded 2023 Royal Medal from the Royal Society
LMB 1978-1979, Sabbatical Visitor, PNAC The Royal Society has awarded Herman Waldmann the Royal Medal 2023 to mark his important contributions to the advancement of knowledge in biological science. Specifically, Herman was recognised for his pioneering research applying monoclonal antibodies for human therapy. Whilst at the LMB, he worked closely with Cesar Milstein and was […]
Joe Greener appointed Group Leader in the LMB’s Structural Studies Division
Joe Greener’s research group in the LMB’s Structural Studies Division will develop differentiable molecular simulation methods to improve biomolecular force fields.