Over 600 pupils from 18 schools across Cambridgeshire, Peterborough and Bedford participated in the 2023 Microscopes4Schools Competition with some impressive entries.
Connecting the microscopic world to children’s everyday lives
Cryo-EM structures reveal the unexpected ability of shelterin to modulate telomeric nucleosomes
Kelly Nguyen’s group, in the LMB’s Structural Studies Division, have solved the cryo-EM structures of a telomeric nucleosome both bound and unbound to shelterin component TRF1, providing novel insights into the molecular interactions between shelterin and nucleosomes.
Chevron shape of TDP-43 in FTLD points to distinct arrangements of TDP-43 as distinguishing feature between neurodegenerative diseases
As previously seen in tau and α-synuclein, Benjamin Ryskeldi-Falcon’s group have determined that TDP-43 forms distinct amyloid arrangements in different neurodegenerative diseases. They describe the structure of filaments of TDP-43 in frontotemporal lobar degeneration (FTLD) as a chevron shape, markedly different from the double spiral shape they previously identified from brains of those with a form […]
The ‘Unknome’ genes which make up a fifth of the human genome
Sean Munro’s group in the LMB’s Cell Biology Division, and Matthew Freeman at the Dunn School of Pathology, University of Oxford, have built the ‘Unknome’ database, which ranks human genes based on how much is known about them. They found that surprisingly little is known about an estimated fifth of the human genome, and that […]
Repurposed DNA repair factors prevent expansions of ‘parasitic’ genomic retrotransposons
Nazareno Bona and Gerry Crossan, in the LMB’s PNAC Division, present a mechanistic explanation of how Fanconi anaemia factors act in a common pathway to restrict LINE-1 retrotransposition.
Muriel Wigby 1932 – 2023
The LMB has sadly learned that Muriel Wigby, who worked as a technician with Sydney Brenner for many years, has died aged 91.