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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > Pore-forming protein perforin-2 is critical to immune response by dendritic cells

Pore-forming protein perforin-2 is critical to immune response by dendritic cells

Pore-forming protein perforin-2 is critical to immune response by dendritic cells

Published on 23 June, 2023

Patrycja Kozik’s group, in the LMB’s PNAC Division, find that the pore-forming protein perforin-2 is an effector of antigen escape in dendritic cells – a critical component to T cell mediated immune responses.

Stephen Wallace wins Norman Heatley Award from Royal Society of Chemistry

Published on 21 June, 2023

LMB 2012-2013, Career Development Fellow, PNAC The Royal Society of Chemistry has announced Stephen Wallace as the 2023 recipient of the Norman Heatley Award. Here, he speaks to the society, covering his career motivations, challenges he’s faced and advice for young chemists. More…

Antiviral Bicycles are effective against SARS-CoV-2

Published on 16 June, 2023

A collaborative study including researchers in Leo James’ group in the LMB’s PNAC Division and Bicycle Therapeutics has developed a new class of antivirals which can be combined together like building blocks to effectively immobilise COVID-19’s Spike protein and block infection.

Neuroprotective protein ADNP is vital to immune reactions to allergens

Published on 7 June, 2023

Using high-throughput CRISPR screening, researchers in Andrew McKenzie’s group in the LMB’s PNAC Division have identified a previously unknown immune-related role for ADNP and identified the molecular mechanism by which it regulates IL-13 expression in allergic immune responses.

Secretary of State visits the LMB 

Published on 30 May, 2023

The LMB recently hosted a visit from Chloe Smith, Secretary of State for Science, Innovation and Technology, where she was shown the latest electron cryo-microscope, installed as part of the government’s World Class Labs investment. During the visit, Chloe Smith spoke to LMB Director Jan Löwe, discussed how LMB researchers use electron cryo-microscopy to look […]

Julian Rayner elected Fellow of the Academy of Medical Sciences

Published on 30 May, 2023

LMB 1993-1998, PhD Student, Postdoctoral scientist, Cell Biology Congratulations to Julian Rayner who has been elected a Fellow of the Academy of Medical Sciences. Julian was a PhD student and then a postdoc in the LMB’s Cell Biology Division, and is now Director of the Cambridge Institute for Medical Research (CIMR) and Director of Wellcome […]

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