In solving the structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome, David Barford’s group in the LMB’s Structural Studies Division has revealed how the complex recognises centromeric DNA and functions as a load-bearing element during chromosome segregation.
Human inner kinetochore structure reveals mechanism for binding DNA during mitosis
LMB research featured in summary of three cryo-EM studies of TMEM106b fibrils found in neurodegenerative diseases
Alzforum summarises three recent papers which analysed TMEM106b amyloid filaments in the human brain – including research from Sjors Scheres’ and Michel Goedert’s groups in the LMB’s Structural Studies and Neurobiology Divisions respectively. More…
In-person public engagement returns after lockdown
In-person public engagement is returning after a long hiatus during the pandemic. LMB scientists took part in British Science Week with schools and at the Cambridge Festival.
Sidney Altman 1939 – 2022
Sidney Altman was a ground-breaking scientist in the field of RNA biology, whose discovery of catalytic properties of RNA led to the award of the Nobel Prize in Chemistry in 1989. His first steps to this discovery began at the LMB, where he worked alongside Sydney Brenner and Francis Crick, research that led to the […]
Structural analysis of GABAA receptors reveals unexpected diversity of arrangements
The Cambridge Independent reports on a recent paper from Radu Aricescu’s group in the LMB’s Neurobiology Division. His group’s structural investigation into type A gamma-aminobutyric acid receptors has found that their subunit arrangements are far more varied than previously thought. More…
Stephen Wallace is the 2023 recipient of The Colworth Medal from The Biochemical Society
Stephen Wallace has been awarded The Colworth Medal, given by The Biochemical Society to recognise outstanding research by a biochemist within 10 years of PhD completion. Stephen was a Career Development Fellow in Jason Chin’s group in the LMB’s PNAC Division, and now is a UKRI Future Leaders Fellow and Senior Lecturer in Biotechnology at […]