Structural analysis of GABAA receptors by Radu Aricescu’s group, in the LMB’s Neurobiology Division, has revealed possibility for an unexpected variety in subunit arrangement, with significant implications for future research and therapeutic developments.
Structural study reveals unexpected diversity in GABAA receptor assembly
Curios of 60 years of the LMB
Celebrating 60 years of the LMB, an exhibition of unusual and intriguing items gives a glimpse into the life and work of the LMB
TMEM106B filaments form in an age-dependent manner in human brains
Inter-divisional collaboration between the groups of Sjors Scheres, Michel Goedert and others identified TMEM106B as a new protein responsible for amyloid filament formation, and showed that these filaments develop in an age-dependent manner in human brains.
Kiyoshi Nagai. 25 June 1949 – 27 September 2019
Kiyoshi Nagai was a preeminent researcher at the LMB for over thirty years during which he was a global leader in the field of spliceosome research. His work culminated in a comprehensive understanding of how the spliceosome catalyses the intrinsic process of gene splicing within eukaryotic cells. His Royal Society Biographical Memoir, written by Andy […]
Carolyn Bertozzi to deliver 2022 Max Perutz Lecture
The 2022 Max Perutz Lecture titled ‘Therapeutic Opportunities in Glycoscience’ will be given by Carolyn Bertozzi at 4PM (BST) on 29th March.
Structural study reveals a novel activation mechanism for the fungal GPCR, Ste2
Chris Tate’s group, in the LMB’s Structural Studies Division, have used cryo-EM analysis to show that Ste2, a fungal Class D GPCR, has a fundamentally distinct activation mechanism in comparison to other types of GPCRs.