Lövestam S,. Li D., Wagstaff J. L., Kotecha A., Kimanius D., McLaughlin S. H., Murzin A. G., Freund S. M. V, Goedert M., Scheres S. H. W.
Disease-specific tau filaments assemble via polymorphic intermediates
Nature 625(7993):119-125DOI: 10.1038/s41586-023-06788-w
PMID: 38030728
PMCID: PMC10764278
Date of Paper: 29/11/2023
Division: Structural StudiesMcMullan G, Naydenova K, Mihaylov D, Yamashita K, Peet MJ, Wilson H, Dickerson JL, Chen S, Cannone G, Lee Y, Hutchings KA, Gittins O, Sobhy MA, Wells T, El-Gomati MM, Dalby J, Meffert M, Schulze-Briese C, Henderson R, Russo CJ.
Structure determination by cryoEM at 100 keV
Proceedings of the National Academy of Sciences of the United States of America 120(49):e2312905120DOI: 10.1073/pnas.2312905120
PMID: 38011573
PMCID: PMC10710074
Date of Paper: 27/11/2023
Division: Protein & Nucleic Acid Chemistry, Structural Studies, NeurobiologyRivron NC, Martinez-Arias A, Sermon K, Mummery C, Schöler HR, Wells J, Nichols J, Hadjantonakis AK, Lancaster MA, Moris N, Fu J, Sturmey RG, Niakan K, Rossant J, Kato K.
Changing the public perception of human embryology
Nature Cell Biology 25(12):1717-1719DOI: 10.1038/s41556-023-01289-4
PMID: 37985870
PMCID:
Date of Paper: 20/11/2023
Division: Cell BiologyNasmyth KA, Lee BG, Roig MB, Löwe J.
What AlphaFold tells us about cohesin's retention on and release from chromosomes
eLife 12:RP88656DOI: 10.7554/eLife.88656
PMID: 37975572
PMCID: PMC10656103
Date of Paper: 17/11/2023
Division: Structural StudiesDrehmann P., Milanos S., Schaefer N., Kasaragod V., Herterich S, Holzbach-Eberle U., Harvey R. J.
Dual role of dysfunctional Asc-1 transporter in distinct human pathologies - human startle disease and developmental delay
eNeuro 0263-23.2023.DOI: 10.1523/ENEURO.0263-23.2023
PMID: 37903619
PMCID: PMC10668224
Date of Paper: 16/11/2023
Division: NeurobiologyStyles CT, Zhou J, Flight KE, Brown JC, Lewis C, Wang X, Vanden Oever M, Peacock TP, Wang Z, Millns R, O'Neill JS, Borodavka A, Grove J, Barclay WS, Tregoning JS, Edgar RS.
Propylene glycol inactivates respiratory viruses and prevents airborne transmission
EMBO Molecular Medicine 15(12):e17932DOI: 10.15252/emmm.202317932
PMID: 37970627
PMCID: PMC10701621
Date of Paper: 16/11/2023
Division: Cell BiologyLin Z., Green E. W., Webster S. G., Hastings M. H., Wilcockson D. C., Kyriacou C. P.
The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach)
Plos Genetics 19(11):e1011047DOI: 10.1371/journal.pgen.1011047
PMID: 37967082
PMCID: PMC10651029
Date of Paper: 15/11/2023
Division: NeurobiologyDickerson J. L., Leahy E., Peet M. J., Naydenova K., Russo C. J.
Accurate magnification determination for cryoEM using gold
Ultramicroscopy 256:113883DOI: 10.1016/j.ultramic.2023.113883
PMID: 38008055
PMCID: PMC10782223
Date of Paper: 15/11/2023
Division: Structural StudiesSun H, Beets I, Schafer W, Hobert O.
Comparing engineered nuclear-localized reporter cassettes
micropublication biology 10.17912/micropub.biology.001014DOI: 10.17912/micropub.biology.001014
PMID: 38021170
PMCID: PMC10654776
Date of Paper: 02/11/2023
Division: NeurobiologyKasaragod V. B., Malinauskas T., Wahid A. A., Lengyel J., Knoflach F., Hardwick S. W., Jones C. F., Chen W. N., Lucas X., El Omari K., Chirgadze D. Y., Aricescu A. R., Cecere G., Hernandez M. C., Miller P. S.
The molecular basis of drug selectivity for α5 subunit-containing GABA(A) receptors
Nature Structural & Molecular Biology 30(12): 1936–1946.DOI: 10.1038/s41594-023-01133-1
PMID: 37903907
PMCID: PMC10716045
Date of Paper: 30/10/2023
Division: NeurobiologyMadan V., Albacete-Albacete L., Jin L., Scaturro P., Watson J. L., Muschalik N., Begum F., Boulanger J., Bauer K., Kiebler M. A., Derivery E., Bullock S. L
HEATR5B associates with dynein-dynactin and promotes motility of AP1-bound endosomal membranes
The EMBO Journal 42(23):e114473DOI: 10.15252/embj.2023114473
PMID: 37872872
PMCID: PMC10690479
Date of Paper: 24/10/2023
Division: Cell BiologyCanon L., Kikuti C., Planelles-Herrero V. J., Lin T., Mayeux F., Sirkia H., Lee Y. I., Heidsieck L., Velikovsky L., David A., Liu X., Moussaoui D., Forest E., Höök P., Petersen K. J., Morgan T. E., Di Cicco A., Sirés-Campos J., Derivery E., Lévy D., Delevoye C., Sweeney H. L., Houdusse A.
How myosin VI traps its off-state, is activated and dimerizes
Nature Communications 14(1):6732DOI: 10.1038/s41467-023-42376-2
PMID: 37872146
PMCID: PMC10593786
Date of Paper: 23/10/2023
Division: Cell BiologyWatson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E.
Macromolecular condensation buffers intracellular water potential
Nature 623(7988):842-852DOI: 10.1038/s41586-023-06626-z
PMID: 37853127
PMCID: PMC10665201
Date of Paper: 18/10/2023
Division: Cell BiologySanford S. A. I., Miller L. V. C, Vaysburd M., Keeling S., Tuck B. J., Clark J., Neumann M., Syanda V., James L. C., McEwan W. A.
The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology
Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationDOI: 10.1002/alz.13493
PMID: 37849026
PMCID: PMC10916982
Date of Paper: 17/10/2023
Division: Protein & Nucleic Acid ChemistryManigrasso G.
Molecular Microbiology Interview-Giulia Manigrasso-Awardee of the best oral presentation at the UK Cellular Microbiology Network Meeting 2023
Molecular MicrobiologyDOI: 10.1111/mmi.15176
PMID: 37804171
PMCID:
Date of Paper: 07/10/2023
Division: Structural StudiesSchweighauser M., Murzin A. G., Macdonald J., Lavenir I., Crowther R. A., Scheres S. H. W., Goedert M.
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Acta Neuropathologica Communications 11(1):160DOI: 10.1186/s40478-023-01658-y
PMID: 37798679
PMCID: PMC10552433
Date of Paper: 05/10/2023
Division: Structural StudiesZaiss D. M. W., Pearce E. J., Artis D., McKenzie A. N. J., Klose C. S. N.
Cooperation of ILC2s and T(H)2 cells in the expulsion of intestinal helminth parasites
Nature reviews. ImmunologyDOI: 10.1038/s41577-023-00942-1
PMID: 37798539
PMCID:
Date of Paper: 05/10/2023
Division: Protein & Nucleic Acid ChemistryWilliams S. L, Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles J. T., Keyser U. F, Waller Z. A., Di Antonio M., Coster G.
Replication-induced DNA secondary structures drive fork uncoupling and breakage
The EMBO Journal 42(22):e114334DOI: 10.15252/embj.2023114334
PMID: 37781931
PMCID: PMC10646557
Date of Paper: 02/10/2023
Division: Protein & Nucleic Acid ChemistryWilliams S. L., Casas-Delucchi C. S., Raguseo F., Guneri D., Li Y., Minamino M., Fletcher E. E., Yeeles JT ., Keyser U. F., Waller Z. A., Di Antonio M., Coster G.
Replication-induced DNA secondary structures drive fork uncoupling and breakage
The EMBO Journal 42(22):e114334DOI: 10.15252/embj.2023114334
PMID: 37781931
PMCID: PMC10646557
Date of Paper: 02/10/2023
Division: Protein & Nucleic Acid ChemistryChiaradia I., Imaz-Rosshandler I., Nilges B. S., Boulanger J., Pellegrini L., Das R., Kashikar N. D., Lancaster M. A.
Tissue morphology influences the temporal program of human brain organoid development
Cell Stem Cell 30(10):1351-1367.e10DOI: 10.1016/j.stem.2023.09.003
PMID: 37802039
PMCID: PMC10765088
Date of Paper: 01/10/2023
Division: Cell BiologyWatson J. L., Krüger L. K., Ben-Sasson A. J., Bittleston A., Shahbazi M. N., Planelles-Herrero V. J., Chambers J. E., Manton J. D., Baker D., Derivery E.
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
Cell 186(21):4710-4727.e35DOI: 10.1016/j.cell.2023.08.034
PMID: 37774705
PMCID: PMC10765089
Date of Paper: 28/09/2023
Division: Cell BiologyLi Z, Shang Z, Liu J, Zhen H, Zhu E, Zhong S, Sturgess RN, Zhou Y, Hu X, Zhao X, Wu Y, Li P, Lin R, Ren J.
D-LMBmap: a fully automated deep-learning pipeline for whole-brain profiling of neural circuitry
Nature Methods 20(10):1593-1604DOI: 10.1038/s41592-023-01998-6
PMID: 37770711
PMCID: PMC10555838
Date of Paper: 28/09/2023
Division: NeurobiologyBasu S, Shukron O, Hall D, Parutto P, Ponjavic A, Shah D, Boucher W, Lando D, Zhang W, Reynolds N, Sober LH, Jartseva A, Ragheb R, Ma X, Cramard J, Floyd R, Balmer J, Drury TA, Carr AR, Needham LM, Aubert A, Communie G, Gor K, Steindel M, Morey L, Blanco E, Bartke T, Di Croce L, Berger I, Schaffitzel C, Lee SF, Stevens TJ, Klenerman D, Hendrich BD, Holcman D, Laue ED.
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
Nature Structural & Molecular Biology 30(11):1628-1639DOI: 10.1038/s41594-023-01095-4
PMID: 37770717
PMCID: PMC10643137
Date of Paper: 28/09/2023
Division: Cell BiologyScheres S. H. W., Ryskeldi-Falcon B., Goedert M.
Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Nature 621(7980):701-710DOI: 10.1038/s41586-023-06437-2
PMID: 37758888
PMCID:
Date of Paper: 27/09/2023
Division: NeurobiologyHowes A. C., Perisic O., Williams R. L.
Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
Science Advances 9(39):eadi8291DOI: 10.1126/sciadv.adi8291
PMID: 37756394
PMCID: PMC10530080
Date of Paper: 27/09/2023
Division: Protein & Nucleic Acid Chemistry