Munasinghe T. S., Edwards M. R., Tsimbalyuk S., Vogel O. A., Smith K. M., Stewart M., Foster J. K., Bosence L. A., Aragão D., Roby J. A., Basler C. F., Forwood J. K.
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity
Nature Communications 13(1):1604. 25 March 2022DOI: 10.1038/s41467-022-28851-2
PMID: 35338144
PMCID: PMC8956657
Date of Paper: 25/03/2022
Division: Structural StudiesMeng B, et al (including Papa G., Mallery D. L., James L. C.)
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
Nature 603(7902):706-714. 24 March 2022DOI: 10.1038/s41586-022-04474-x
PMID: 35104837
PMCID: PMC8942856
Date of Paper: 24/03/2022
Division: Protein & Nucleic Acid ChemistryVelazhahan V., Ma N., Vaidehi N., Tate C. G.
Activation mechanism of the class D fungal GPCR dimer Ste2
Nature 603(7902):743-748. 24 March 2022DOI: 10.1038/s41586-022-04498-3
PMID: 35296853
PMCID: PMC8942848
Date of Paper: 24/03/2022
Division: Structural StudiesDickerson J. L., Russo C. J.
Phase contrast imaging with inelastically scattered electrons from any layer of a thick specimen
Ultramicroscopy e-pub: published online 19 March 2022DOI: 10.1016/j.ultramic.2022.113511
PMID: 35367902
PMCID: PMC9355894
Date of Paper: 19/03/2022
Division: Structural StudiesDickerson J. L., Lu P. H., Hristov D., Dunin-Borkowski R. E., Russo C. J.
Imaging biological macromolecules in thick specimens: The role of inelastic scattering in cryoEM
Ultramicroscopy e-pub: published online 19 March 2022DOI: 10.1016/j.ultramic.2022.113510
PMID: 35367900
PMCID: PMC9355893
Date of Paper: 19/03/2022
Division: Structural StudiesNaydenova K., Kamegawa A., Peet M. J., Henderson R., Fujiyoshi Y., Russo C. J.
On the reduction in the effects of radiation damage to two-dimensional crystals of organic and biological molecules at liquid-helium temperature
Ultramicroscopy e-pub: published online 19 March 2022DOI: 10.1016/j.ultramic.2022.113512
PMID: 35367901
PMCID: PMC9355890
Date of Paper: 19/03/2022
Division: Structural StudiesKoch A. A., Bagnall J. S., Smyllie N. J., Begley N., Adamson A. D., Fribourgh J. L., Spiller D. G., Meng Q. J., Partch C. L., Strimmer K., House T. A., Hastings M. H., Loudon A. S. I.
Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock
Elife 11:e73976. 14 March 2022DOI: 10.7554/elife.73976
PMID: 35285799
PMCID: PMC8983044
Date of Paper: 14/03/2022
Division: NeurobiologyHegde R. S.
The Function, Structure, and Origins of the ER Membrane Protein Complex
Annual Review of Biochemistry e-pub: published online 14 March 2022DOI: 10.1146/annurev-biochem-032620-104553
PMID: 35287476
PMCID:
Date of Paper: 14/03/2022
Division: Cell BiologyLövestam S, Scheres SHW.
High-throughput cryo-EM structure determination of amyloids
Faraday Discussions Nov 8;240(0):243-260DOI: 10.1039/d2fd00034b
PMID: 35913272
PMCID: PMC9642048
Date of Paper: 14/03/2022
Division: Structural StudiesCosway E. J., White A. J., Parnell S. M., Schweighoffer E., Jolin H. E., Bacon A., Rodewald H. R., Tybulewicz V., McKenzie A. N. J., Jenkinson W. E., Anderson G.
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
Science Immunology 7(69):eabn3286. 11 March 2022DOI: 10.1126/sciimmunol.abn3286
PMID: 35275754
PMCID: PMC7612579
Date of Paper: 11/03/2022
Division: Protein & Nucleic Acid ChemistryTang X., Chen R., Mesias V. S. D., Wang T., Wang Y., Poljak K., Fan X., Miao H., Hu J., Zhang L., Huang J., Yao S., Miller E. A., Guo Y.
A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog
Proceedings of the National Academy of Sciences of the United States of America 119(11):e2113991119. 10 March 2022DOI: 10.1073/pnas.2113991119
PMID: 35271396
PMCID: PMC8931250
Date of Paper: 10/03/2022
Division: Cell BiologyOsman M. M., Shanahan J. K., Chu F., Takaki K. K., Pinckert M. L., Pagán A. J., Brosch R., Conrad W. H., Ramakrishnan L.
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence
Proceedings of the National Academy of Sciences of the United States of America 119(11):e2122161119. 10 March 2022DOI: 10.1073/pnas.2122161119
PMID: 35271388
PMCID: PMC8931374
Date of Paper: 10/03/2022
Division: Cell BiologyRoberts S. J., Liu Z., Sutherland J. D.
Potentially Prebiotic Synthesis of Aminoacyl-RNA via a Bridging Phosphoramidate-Ester Intermediate
Journal of the American Chemical Society 144(9):4254-4259. 9 March 2022DOI: 10.1021/jacs.2c00772
PMID: 35230111
PMCID: PMC9097472
Date of Paper: 09/03/2022
Division: Protein & Nucleic Acid ChemistryLövestam S., Koh F. A., van Knippenberg B., Kotecha A., Murzin A. G., Goedert M., Scheres S. H. W.
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
Elife 11:e76494. 4 March 2022DOI: 10.7554/elife.76494
PMID: 35244536
PMCID: PMC8983045
Date of Paper: 04/03/2022
Division: Neurobiology, Structural StudiesWarshamanage R., Yamashita K., Murshudov G. N.
EMDA: A Python package for Electron Microscopy Data Analysis
Journal of Structural Biology 214(1):107826. March 2022DOI: 10.1016/j.jsb.2021.107826
PMID: 34915128
PMCID: PMC8935390
Date of Paper: 01/03/2022
Division: Structural StudiesChen S., Li J., Vinothkumar K. R., Henderson R.
Interaction of human erythrocyte catalase with air-water interface in cryoEM
Microscopy 71(Supplement_1):i51-i59. March 2022DOI: 10.1093/jmicro/dfab037
PMID: 35275189
PMCID: PMC8855524
Date of Paper: 01/03/2022
Division: Structural StudiesAlvin Yu, Elizabeth M Y Lee, John A G Briggs, Barbie K Ganser-Pornillos, Owen Pornillos, Gregory A Voth
Strain and rupture of HIV-1 capsids during uncoating
Proceedings of the National Academy of Sciences of the United States of America Mar 8;119(10):e2117781119DOI: 10.1073/pnas.2117781119
PMID: 35238630
PMCID: PMC8915963
Date of Paper: 01/03/2022
Division: Structural StudiesJomaa A., Gamerdinger M., Hsieh H. H., Wallisch A., Chandrasekaran V., Ulusoy Z., Scaiola A., Hegde R. S., Shan S. O., Ban N., Deuerling E.
Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting
Science 375(6583):839-844. 25 February 2022DOI: 10.1126/science.abl6459
PMID: 35201867
PMCID: PMC7612438
Date of Paper: 25/02/2022
Division: Cell Biology, Structural StudiesStewart M.
Function of the Nuclear Transport Machinery in Maintaining the Distinctive Compositions of the Nucleus and Cytoplasm
International Journal of Molecular Sciences 23(5):2578. 25 February 2022DOI: 10.3390/ijms23052578
PMID: 35269721
PMCID: PMC8910404
Date of Paper: 25/02/2022
Division: Structural StudiesTang S., Beattie A. T., Kafkova L., Petris G., Huguenin-Dezot N., Fiedler M., Freeman M., Chin J. W.
Mechanism-based traps enable protease and hydrolase substrate discovery
Nature 602(7898):701-707. 24 February 2022DOI: 10.1038/s41586-022-04414-9
PMID: 35173328
PMCID: PMC8866121
Date of Paper: 24/02/2022
Division: Protein & Nucleic Acid ChemistrySekne Z., Ghanim G. E., van Roon A. M., Nguyen T. H. D.
Structural basis of human telomerase recruitment by TPP1-POT1
Science 375(6585):1173-1176DOI: 10.1126/science.abn6840
PMID: 35201900
PMCID: PMC7612489
Date of Paper: 24/02/2022
Division: Structural StudiesValperga G., de Bono M.
Impairing one sensory modality enhances another by reconfiguring peptidergic signalling in Caenorhabditis elegans
Elife 11:e68040. 24 February 2022DOI: 10.7554/elife.68040
PMID: 35201977
PMCID: PMC8871372
Date of Paper: 24/02/2022
Division: Cell BiologyPak A. J., Yu A., Ke Z., Briggs J. A. G., Voth G. A.
Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core
Nature Communications 13(1):1002. 22 February 2022DOI: 10.1038/s41467-022-28654-5
PMID: 35194049
PMCID: PMC8863989
Date of Paper: 22/02/2022
Division: Structural StudiesChou Y. H., Yang C. J., Huang H. W., Liou N. F., Panganiban M. R., Luginbuhl D., Yin Y., Taisz I., Liang L., Jefferis G. S. X. E., Luo L.
Mating-driven variability in olfactory local interneuron wiring
Science Advances 8(7):eabm7723. 18 February 2022DOI: 10.1126/sciadv.abm7723
PMID: 35179957
PMCID: PMC8856614
Date of Paper: 18/02/2022
Division: NeurobiologyTravers A.
Why DNA? From DNA sequence to biological complexity.
Why DNA? From DNA sequence to biological complexity.DOI:
PMID:
PMCID:
Date of Paper: 17/02/2022
Division: Cell Biology