Boyle K. B., Ellison C. J., Elliott P. R., Schuschnig M., Grimes K., Dionne M. S., Sasakawa C., Munro S., Martens S., Randow F.
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure
The EMBO Journal 42(17):e113012DOI: 10.15252/embj.2022113012
PMID: 37409490
PMCID: PMC10476172
Date of Paper: 06/06/2023
Division: Protein & Nucleic Acid ChemistryFerreira A. C. F., Szeto A. C. H., Clark P. A., Crisp A., Kozik P., Jolin H. E., McKenzie A. N. J.
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
Immunity 56(7):1468-1484.e7DOI: doi.org/10.1016/j.immuni.2023.05.010
PMID: 37285842
PMCID: PMC10501989
Date of Paper: 06/06/2023
Division: Protein & Nucleic Acid ChemistryHöpfler M., Absmeier E., Peak-Chew S. Y., Vartholomaiou E., Passmore L. A.,. Gasic I., Hegde R. S.
Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation
Molecular Cell 83(13):2290-2302.e13DOI: 10.1016/j.molcel.2023.05.020
PMID: 37295431
PMCID: PMC10403363
Date of Paper: 02/06/2023
Division: Cell BiologyRibeiro J, Crossan G.P.
GCNA is a histone binding protein required for spermatogonial stem cell maintenance
Nucleic Acids Research 51(10):4791-4813DOI: 10.1093/nar/gkad168
PMID: 36919611
PMCID: PMC10250205
Date of Paper: 01/06/2023
Division: Protein & Nucleic Acid ChemistryRibeiro J., Crossan G. P.
GCNA is a histone binding protein required for spermatogonial stem cell maintenance
Nucleic Acids Research 51(10):4791-4813DOI: 51(10):4791-4813
PMID: 36919611
PMCID: PMC10250205
Date of Paper: 01/06/2023
Division: Structural StudiesDimou E., Katsinelos T., Meisl G., Tuck B. J., Keeling S., Smith A. E., Hidari E., Lam J. Y. L., Burke M., Lövestam S., Ranasinghe R. T., McEwan W.A., Klenerman D.
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
Cell Reports 42(7):112725DOI: 10.1016/j.celrep.2023.112725
PMID: 37393617
PMCID: PMC7614924
Date of Paper: 01/06/2023
Division: Structural StudiesAgirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K.
The CCP4 suite: integrative software for macromolecular crystallography
Acta crystallographica. Section D, Structural Biology 79(Pt 6):449-461DOI: 10.1107/s2059798323003595
PMID: 37259835
PMCID: PMC10233625
Date of Paper: 30/05/2023
Division: Structural StudiesBravo-Plaza I., Tagua V. G., Arst H. N. Jr, Alonso A., Pinar M., Monterroso B., Galindo A., Peñalva M. A.
The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain
Elife 12:e85079DOI: 10.7554/elife.85079
PMID: 37249218
PMCID: PMC10275640
Date of Paper: 30/05/2023
Division: Cell BiologyAgirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K.
The CCP4 suite: integrative software for macromolecular crystallography
Acta crystallographica. Section D, Structural Biology 79(Pt 6):449-461DOI: 10.1107/s2059798323003595
PMID: 37259835
PMCID: PMC10233625
Date of Paper: 30/05/2023
Division: Structural StudiesHastings M. H., Brancaccio M., Gonzalez-Aponte M. F., Herzog E. D.
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly
Annual Review of Neuroscience 46:123-143DOI: 10.1146/annurev-neuro-100322-112249
PMID: 36854316
PMCID: PMC10381027
Date of Paper: 28/05/2023
Division: NeurobiologyHakanpää L., Abouelezz A., Lenaerts A. S., Culfa S., Algie M., Bärlund J., Katajisto P., McMahon H., Almeida-Souza L.
Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1
The Journal of Cell Biology 222(8):e202303107DOI: 10.1083/jcb.202303107
PMID: 37233325
PMCID: PMC10225744
Date of Paper: 26/05/2023
Division: NeurobiologyHakanpää L., Abouelezz A., Lenaerts A. S., Culfa S, Algie M., Bärlund J., Katajisto P., McMahon H., Almeida-Souza L.
Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1
The Journal of Cell Biology 222(8):e202303107DOI: 0.1083/jcb.202303107
PMID: 37233325
PMCID: PMC10225744
Date of Paper: 26/05/2023
Division: NeurobiologyZhang D., Lape R., Shaikh S. A., Kohegyi B. K., Watson J. F., Cais O., Nakagawa T., Greger I. H
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
Nature Communication 14(1):1659DOI: 10.1038/s41467-023-37259-5
PMID: 36966141
PMCID: PMC10039940
Date of Paper: 25/05/2023
Division: NeurobiologyLemus L., Hegde R. S, Goder V.
New frontiers in quality control: the case of GPI-anchored proteins
Nature reviews. Molecular Cell BiologyDOI: 10.1038/s41580-023-00616-9
PMID: 37231113
PMCID:
Date of Paper: 25/05/2023
Division: Cell BiologyGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature 618(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Protein & Nucleic Acid ChemistryGong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Nature 18(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Protein & Nucleic Acid ChemistryStern A. M., Yang Y., Jin S., Yamashita K., Meunier A. L., Liu W., Cai Y., Ericsson M., Liu L., Goedert M., Scheres S. H. W., Selkoe D. J.
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
Nature 618(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Structural StudiesGáspár I., Phea L. J, McClintock M. A., Heber S., Bullock S. L, Ephrussi A.
An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport
The Journal of Cell Biology 222(7):e202301113DOI: 10.1083/jcb.202301113
PMID: 37213090
PMCID: 10202831
Date of Paper: 22/05/2023
Division: Cell BiologyWit N., Gogola E., West J. A., Vornbäumen T., Seear R. V., Bailey P. S. J., Burgos-Barragan G., Wang M., Krawczyk P., Huberts D. H. E. W., Gergely F., Matheson N. J., Kaser A., Nathan J. A., Patel K. J.
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production
Science Advances 9(20):eadg2235DOI: 10.1126/sciadv.adg2235
PMID: 37196082
PMCID: PMC10191432
Date of Paper: 17/05/2023
Division: Protein & Nucleic Acid ChemistryOuellet S., Ferguson L., Lau A. Z, Lim T. K. Y.
CysPresso: a classification model utilizing deep learning protein representations to predict recombinant expression of cysteine-dense peptides
BMC Bioinformatics 24(1):200DOI: 10.1186/s12859-023-05327-8
PMID: 37193950
PMCID: PMC10189939
Date of Paper: 16/05/2023
Division: NeurobiologyPatton A. P., Morris E. L., McManus D., Wang H., Li Y., Chin J. W., Hastings M. H.
Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus
Proceedings of the National Academy of Sciences of the United States of America 120(21):e2301330120DOI: 10.1073/pnas.2301330120
PMID: 37186824
PMCID: PMC10214171
Date of Paper: 15/05/2023
Division: Protein & Nucleic Acid ChemistrySu M., Schmitt C., Liu Z., Roberts S. J., Liu K. C., Röder K., Jäschke A., Wales D. J., Sutherland J. D.
Triplet-Encoded Prebiotic RNA Aminoacylation
bioRxiv 145(29):15971-15980DOI: doi.org/10.1021/jacs.3c03931
PMID: 37435826
PMCID:
Date of Paper: 13/05/2023
Division: Protein & Nucleic Acid ChemistryStern A. M., Yang Y., Jin S., Yamashita K., Meunier A. L., Liu W., Cai Y., Ericsson M., Liu L., Goedert M., Scheres S. H. W., Selkoe D. J.
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
Neuron 111(13):2012-2020.e4DOI: 10.1016/j.neuron.2023.04.007
PMID: 37167969
PMCID:
Date of Paper: 10/05/2023
Division: Structural StudiesWozny M.R., Di Luca A., Morado D. R., Picco A., Khaddaj R,. Campomanes P., Ivanović L., Hoffmann P. C., Miller E. A, Vanni S., Kukulski W.
In situ architecture of the ER-mitochondria encounter structure
Nature 618(7963):188-192DOI: 10.1038/s41586-023-06050-3
PMID: 37165187
PMCID: PMC7614606
Date of Paper: 10/05/2023
Division: Cell BiologyWozny M. R., Di Luca A., Morado D. R., Picco A, Khaddaj R., Campomanes P., Ivanović L., Hoffmann P. C., Miller E.A., Vanni S., Kukulski W.
In situ architecture of the ER-mitochondria encounter structure
Nature 618(7963):188-192DOI: doi.org/10.1038/s41586-023-06050-3
PMID: 37165187
PMCID: PMC7614606
Date of Paper: 10/05/2023
Division: Cell Biology