Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Nature 18(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Protein & Nucleic Acid ChemistryStern A. M., Yang Y., Jin S., Yamashita K., Meunier A. L., Liu W., Cai Y., Ericsson M., Liu L., Goedert M., Scheres S. H. W., Selkoe D. J.
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
Nature 618(7963):159-168DOI: 10.1038/s41586-023-05972-2
PMID: 37225977
PMCID: PMC7614683
Date of Paper: 24/05/2023
Division: Structural StudiesBolton R, Machelett MM, Stubbs J, Axford D, Caramello N, Catapano L, Malý M, Rodrigues MJ, Cordery C, Tizzard GJ, MacMillan F, Engilberge S, von Stetten D, Tosha T, Sugimoto H, Worrall JAR, Webb JS, Zubkov M, Coles S, Mathieu E, Steiner RA, Murshudov G, Schrader TE, Orville AM, Royant A, Evans G, Hough MA, Owen RL, Tews I.
A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus
Proceedings of the National Academy of Sciences of the United States of America 121(12):e2308478121DOI: 10.1073/pnas.2308478121
PMID: 38489389
PMCID: PMC10962944
Date of Paper: 23/05/2023
Division: Structural StudiesGáspár I., Phea L. J, McClintock M. A., Heber S., Bullock S. L, Ephrussi A.
An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport
The Journal of Cell Biology 222(7):e202301113DOI: 10.1083/jcb.202301113
PMID: 37213090
PMCID: 10202831
Date of Paper: 22/05/2023
Division: Cell BiologyWit N., Gogola E., West J. A., Vornbäumen T., Seear R. V., Bailey P. S. J., Burgos-Barragan G., Wang M., Krawczyk P., Huberts D. H. E. W., Gergely F., Matheson N. J., Kaser A., Nathan J. A., Patel K. J.
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production
Science Advances 9(20):eadg2235DOI: 10.1126/sciadv.adg2235
PMID: 37196082
PMCID: PMC10191432
Date of Paper: 17/05/2023
Division: Protein & Nucleic Acid ChemistryOuellet S., Ferguson L., Lau A. Z, Lim T. K. Y.
CysPresso: a classification model utilizing deep learning protein representations to predict recombinant expression of cysteine-dense peptides
BMC Bioinformatics 24(1):200DOI: 10.1186/s12859-023-05327-8
PMID: 37193950
PMCID: PMC10189939
Date of Paper: 16/05/2023
Division: NeurobiologyPatton A. P., Morris E. L., McManus D., Wang H., Li Y., Chin J. W., Hastings M. H.
Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus
Proceedings of the National Academy of Sciences of the United States of America 120(21):e2301330120DOI: 10.1073/pnas.2301330120
PMID: 37186824
PMCID: PMC10214171
Date of Paper: 15/05/2023
Division: Protein & Nucleic Acid ChemistrySu M., Schmitt C., Liu Z., Roberts S. J., Liu K. C., Röder K., Jäschke A., Wales D. J., Sutherland J. D.
Triplet-Encoded Prebiotic RNA Aminoacylation
bioRxiv 145(29):15971-15980DOI: doi.org/10.1021/jacs.3c03931
PMID: 37435826
PMCID: PMC10375532
Date of Paper: 13/05/2023
Division: Protein & Nucleic Acid ChemistryStern A. M., Yang Y., Jin S., Yamashita K., Meunier A. L., Liu W., Cai Y., Ericsson M., Liu L., Goedert M., Scheres S. H. W., Selkoe D. J.
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
Neuron 111(13):2012-2020.e4DOI: 10.1016/j.neuron.2023.04.007
PMID: 37167969
PMCID: PMC10330525
Date of Paper: 10/05/2023
Division: Structural StudiesWozny M.R., Di Luca A., Morado D. R., Picco A., Khaddaj R,. Campomanes P., Ivanović L., Hoffmann P. C., Miller E. A, Vanni S., Kukulski W.
In situ architecture of the ER-mitochondria encounter structure
Nature 618(7963):188-192DOI: 10.1038/s41586-023-06050-3
PMID: 37165187
PMCID: PMC7614606
Date of Paper: 10/05/2023
Division: Cell BiologyWozny M. R., Di Luca A., Morado D. R., Picco A, Khaddaj R., Campomanes P., Ivanović L., Hoffmann P. C., Miller E.A., Vanni S., Kukulski W.
In situ architecture of the ER-mitochondria encounter structure
Nature 618(7963):188-192DOI: doi.org/10.1038/s41586-023-06050-3
PMID: 37165187
PMCID: PMC7614606
Date of Paper: 10/05/2023
Division: Cell BiologyBafna A., Banks G., Hastings M. H., Nolan P. M.
Dynamic modulation of genomic enhancer elements in the suprachiasmatic nucleus, the site of the mammalian circadian clock
Genome Research 33(5):673-688DOI: 10.1101/gr.277581.122
PMID: 37156620
PMCID: PMC10317116
Date of Paper: 08/05/2023
Division: NeurobiologyGreen N. J., Russell D. A., Tanner S. H., Sutherland J. D.
Prebiotic Synthesis of N-Formylaminonitriles and Derivatives in Formamide
Journal of the American Chemical Society 145(19):10533-10541DOI: doi.org/10.1021/jacs.2c13306
PMID: 37146260
PMCID: PMC10197134
Date of Paper: 05/05/2023
Division: Protein & Nucleic Acid ChemistryQi C., Hasegawa M., Takao M., Sakai M., Sasaki M., Mizutani M., Akagi A., Iwasaki Y., Miyahara H., Yoshida M., Scheres S. H. W., Goedert M.
Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
Acta Neuropathologica Communications 11(1):74DOI: 10.1186/s40478-023-01565-2
PMID: 37143123
PMCID: PMC10161654
Date of Paper: 05/05/2023
Division: Structural StudiesYamashita K., Wojdyr M., Long F., Nicholls R. A., Murshudov G. N.
GEMMI and Servalcat restrain REFMAC5
Acta crystallographica. Section D, Structural Biology 79(Pt 5):368-373DOI: 10.1107/s2059798323002413
PMID: 37158197
PMCID: PMC10167671
Date of Paper: 04/05/2023
Division: Structural StudiesDhillon P., Skourti E., Passmore L. A.
In conversation with Lori Passmore
The FEBS JournalDOI: 10.1111/febs.16782
PMID: 37138518
PMCID:
Date of Paper: 03/05/2023
Division: Structural StudiesShiu P. K., Sterne G. R., Spiller N., Franconville R., Sandoval A., Zhou J., Simha N., Kang C. H., Yu S., Kim J. S., Dorkenwald S., Matsliah A., Schlegel P., Yu S. C., McKellar C. E., Sterling A., Costa M., Eichler K., Jefferis G. S. X. E., Murthy M., Bates A. S., Eckstein N., Funke J., Bidaye S. S., Hampel S., Seeds A. M., Scott K.
A leaky integrate-and-fire computational model based on the connectome of the entire adult Drosophila brain reveals insights into sensorimotor processing
bioRxivDOI: 10.1101/2023.05.02.539144
PMID: PPR653992
PMCID: PMC10187186
Date of Paper: 02/05/2023
Division: NeurobiologyLiu T., Meng Z., Liu J., Li J., Zhang Y., Deng Z., Luo S., Wang M., Huang Q., Zhang S., Fendt P., Devouassoux J., Li D., McKenzie A. N. J., Nahrendorf M., Libby P., Guo J., Shi G. P.
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells
Cardiovascular Research 119(4):1046-1061DOI: 10.1093/cvr/cvac144
PMID: 36063432
PMCID: PMC10153644
Date of Paper: 01/05/2023
Division: Protein & Nucleic Acid ChemistryGerecht K., Freund N., Liu W., Liu Y., Fürst M. J. L. J., Holliger P.
The Expanded Central Dogma: Genome Resynthesis, Orthogonal Biosystems, Synthetic Genetics
Annual Review of Biophysics 52:413-432DOI: 10.1146/annurev-biophys-111622-091203
PMID: 37159296
PMCID: PMC7614659
Date of Paper: 01/05/2023
Division: Protein & Nucleic Acid ChemistryKäshammer L., van den Ent F., Jeffery M., Jean N. L., Hale V. L., Löwe J.
Cryo-EM structure of the bacterial divisome core complex and antibiotic target FtsWIQBL
Nature Microbiology 8(6):1149-1159DOI: doi.org/10.1038/s41564-023-01368-0
PMID: 37127704
PMCID: PMC7614612
Date of Paper: 01/05/2023
Division: Structural StudiesHealy M. D., McNally K. E., Butkovič R., Chilton M., Kato K., Sacharz J., McConville C., Moody E. R. R., Shaw S., Planelles-Herrero V. J., Yadav S.K. N., Ross J., Borucu U., Palmer C. S., Chen K. E., Croll T. I., Hall R. J., Caruana N. J., Ghai R., Nguyen T. H. D., Heesom K. J., Saitoh S., Berger I., Schaffitzel C., Williams T. A, Stroud D. A., Derivery E., Collins B. M., Cullen P. J.
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome
Cell 6(10):2219-2237.e29DOI: doi.org/10.1016/j.cell.2023.04.003
PMID: 37172566
PMCID: PMC10187114
Date of Paper: 01/05/2023
Division: Cell BiologyKäshammer L., van den Ent F., Jeffery M., Jean N. L., Hale V. L., Löwe J.
Cryo-EM structure of the bacterial divisome core complex and antibiotic target FtsWIQBL
Nature Microbiology 8(6):1149-1159DOI: 10.1038/s41564-023-01368-0
PMID: 37127704
PMCID: 37127704
Date of Paper: 01/05/2023
Division: Structural StudiesGómez-Escribano A.P., Mora-Martínez C., Roca M., Walker D. S., Panadero J., Sequedo M.D., Saini R., Knölker H.J., Blanca J., Burguera J., Lahoz A., Cañizares J., Millán J. M., Burton N.O., Schafer W.R., Vázquez-Manrique R.P.
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans
EMBO Reports 24(6):e55556DOI: 10.15252/embr.202255556
PMID: 37103980
PMCID: PMC10240203
Date of Paper: 27/04/2023
Division: NeurobiologyGómez-Escribano A. P, Mora-Martínez C., Roca M., Walker D. S., Panadero J., Sequedo M. D., Saini R., Knölker H. J., Blanca J., Burguera J, Lahoz A., Cañizares J., Millán J. M., Burton N. O., Schafer W. R., Vázquez-Manrique R. P.
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans
EMBO Reports, 24(6):e55556DOI: 10.15252/embr.202255556
PMID: 37103980
PMCID: PMC10240203
Date of Paper: 27/04/2023
Division: NeurobiologyGómez-Escribano A. P., Mora-Martínez C., Roca M., Walker D. S., Panadero J., Sequedo M. D., Saini R., Knölker H. J, Blanca J., Burguera J., Lahoz A., Cañizares J., Millán J. M., Burton N. O., Schafer W. R., Vázquez-Manrique R. P.
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans
EMBO Reports 24(6):e55556DOI: 10.15252/embr.202255556
PMID: 37103980
PMCID: PMC10240203
Date of Paper: 27/04/2023
Division: Neurobiology