Category Archives: Image365
This photo for day 330 of #LMB365 was taken by our Estates & Facilities Manager during one of his routine walks around the LMB site and shows some beautiful fungi that have come up in one of the flowerbeds outside the front of the LMB building.
Day 329 of #LMB365 shows the cryo-EM structure of the human 20S proteasome bound to PA200. This provides significant new information on this important but still poorly studied protein complex located in the nucleus of cells. This structure, by Ana Toste Rêgo and Paula da Fonseca, was determined by the analysis of a sample obtained by the recombinant co-expression of all the complex 15 constitutive subunits together with its 5 dedicated assembly chaperones
Day 328 of #LMB365 shows a view of the illuminated staircase from the LMB’s restaurant. The restaurant is situated on the top floor of the building, as it was in the original LMB building, and the staircase is always busy during the day.
Day 327 of #LMB365 shows Group Leader Kelly Nguyen preparing some cryo-EM grids. A tiny drop of sample is applied to an EM grid inside a “Vitrobot”. After applying the sample, it is incubated at 4°C and 100% humidity to let the grid adsorb the sample without drying out. After incubation, the “Vitrobot” blots most of the sample away, leaving a thin layer of sample, which is then rapidly plunged into liquid ethane for vitrification.
A stormy day over the Cambridge Biomedical Campus and the LMB, captured here for day 326 of #LMB365 by Alexey Murzin. One end of the rainbow is over the new Royal Papworth Hospital.
Day 325 of #LMB365 shows the LMBees being excited by all the new cutting edge techniques presented at the recent Next Generation Biophysics meeting https://www3.mrc-lmb.cam.ac.uk/sites/nextgen/ that brought scientists from academia and industry together to discuss new developments. All the speakers were given their LMBees as a memento of their visit to the LMB. We hope they will all return next year for the next installment
This image for day 324 of #LMB365 shows a cryo-EM visualisation of a G protein-coupled receptor reconstituted into a lipid nanodisc and then coupled to beta-arrestin from Chris Tate’s group in the Structural Studies Division
Asymmetric cell division is the process by which one cell gives rise to two daughters that have different fate. Asymmetric cell division is the hallmark of stem cells, which generate all the different cell types in the organism. The Derivery Lab in the Cell Biology Division uses the fruit fly to study the molecular mechanism of asymmetric cell division as it is amenable to imaging and genetic modifications. This image for day 323 of #LMB365 represents the back of the fly (called the notum), where all the cells express a cytoskeleton marker in green, while only the cells dividing asymmetrically express a red marker. These cells form a remarkable aligned array, which will give rise to the mechanosensory bristles on the adult fly.
Day 322 of #LMB365 shows Li Jin and Christine Hilcenko setting up their stand at the LMB for a charity cake sale in support of The Raymond Nicolet Trust. The sale achieved an amazing £178 that will fully go to support educational establishments in Serbia.
If you have ever wondered how all the glass in the atrium of the LMB is kept clean, this photo for day 321 of #LMB365 shows you how. This is carried out biennially and takes two people 8 days to clean all the glass, including the fascia boards, high girders, tops of pods, and floodlights. Throughout the process care is taken to protect the atrium floor.