Day 99 of #LMB365 is a journal cover design by Lesley McKeane in the LMB’s Visual Aids team. The selective coupling of G-protein-coupled receptors (GPCRs) to specific G proteins is critical to trigger the appropriate physiological response. This image represents this selective binding using the analogy of multiple keys (receptors) opening the same lock (G protein, orange).
Image365
LMB 365 – Day 98
Our building is comprised of more than 25,000 square metres of glass, inside and out. All this glass allows for stunning views of our surroundings and on day 98 of #LMB365, we look past the Director’s suite at the sun setting over the nearby nature reserve.
LMB 365 – Day 97
Day 97 of #LMB365 shows a precious column collection mounted on the wall of a cold room using aluminium holders designed by the LMB’s Director and made in the Technical Instrumentation Workshop. This is an essential part of the preparation of samples for the Structural Studies Division. The columns are filled with special resins that separate the injected protein samples based on their affinity for such resins, or on their charge or size. Dependent on the sample size and purification step, the columns need to be of different diameter, length and volume.
LMB 365 – Day 96
Jim Watson was born on this day in 1928. He joined the MRC Unit in Cambridge in 1951, where he met and began working with Francis Crick. He was just 25 when together they revealed the structure of DNA, for which they were awarded the 1962 @NobelPrize for Physiology or Medicine. This photo of Jim, on day 96 of #LMB365 was taken by research student Hans Boye in a corridor of the old LMB in 1962
LMB 365 – Day 95
On day 95 of LMB365 we have a picture by Katja Röper in the Cell Biology Division. This image shows the flat epithelial patch of cells in the Drosophila embryo that will form the tubes of the salivary glands over a the time span of a few hours. The cell membranes are labelled and the image shows cell outlines at three different depths through the cells, each depth in a different shade of colour. This visualisation therefore allows an appreciation of 3D cell shapes.
LMB 365 – Day 94
Day 94 of #LMB365 image by Philipp Schlegel (Jefferis lab, Neurobiology Division) shows olfactory projection neurons in the poppy seed-sized brain of the fruit fly Drosophila melanogaster. Each dot is one of ~57k axonal presynapses coloured by neuron type. This data was produced through EM reconstruction in collaboration with Davi Bock (Janelia Research Campus) and is used to study circuits for instinctive olfactory behaviour.