Day 213 of #LMB365 shows a set of 29 DNP-derivatives of amino acids, prepared by Fred Sanger for his work on the sequencing of proteins. This work led to the sequencing of insulin, as reported on this day in 1955, in a landmark paper in the Biochemical Journal, “[this] was essentially the climax of our work on insulin. It was the first protein to be sequenced and we had developed methods and demonstrated their applicability. I think this stimulated interest in sequencing in other laboratories, and our methods were used extensively until better ones were available.” Fred Sanger, Selected papers of Frederick Sanger (with commentaries) World Scientific, 1996. Fred received the first of his two Nobel Prizes in Chemistry for this work.
LMB 365 – Day 213
Germ cells need DNA crosslink repair to develop normally
Germ cells face a significant threat to their genetic integrity during embryonic development. Ross Hill and Gerry Crossan, of the Crossan Group in the LMB’s PNAC Division, have recently found that these cells need a specific form of DNA repair, known as crosslink repair, in order to develop normally. The findings have been published online […]
LMB 365 – Day 212
Day 212 of #LMB365 shows managers of some of the LMB’s Operations Group teams hard at work in a risk assessment workshop delivered by the LMB’s Health & Safety team. The LMB has an in-house H&S team and they work with all staff to provide advice and support on H&S matters to help keep both the science and the support infrastructure running smoothly and safely.
LMB 365 – Day 211
Day 211 of #LMB365 shows a cerebral organoid section with large ventricles from Laura Pellegrini in Madeline Lancaster’s group in Cell Biology. Cell nuclei are labelled in blue and the apical marker ZO1 in white highlights the perimeter of the ventricle. These organoids can model the architecture of a developing human brain.
LMB 365 – Day 210
The LMB Graduate Student Association (GSA) held its first ever LGBT+ Happy Hour social event recently, which was open to everyone across the LMB. This photo for day 210 of #LMB365 shows some of the attendees enjoying themselves in the early evening sunshine. The GSA is run by and for students and organises social, educational and welfare events throughout the year.
LMB 365 – Day 209
This shot of the LMB for day 209 of #LMB365 was taken by Oleksiy Kovtun. The stainless steel façade of the plant towers was installed by hand by a company called Varla. The discharge from each of the flues on the towers is the equivalent of a transit van of air every second and ensures the building is supplied with fresh, environmentally controlled air.