Whilst a mother’s metabolism provides essential nutrients to enable embryonic development, both mother and embryo can also produce reactive metabolites that can damage DNA. Research undertaken by Nina Oberbeck in KJ Patel’s group, in the LMB’s PNAC Division, has uncovered how the embryo is protected from these genotoxins. Birth defects are common and are a […]
The mother’s role in protecting the fetal genome from aldehyde damage is revealed.
John Sutherland awarded the 2014 Royal Society Darwin Medal
John Sutherland, from the LMB’s Protein and Nucleic Acid Chemistry Division, has been awarded the Royal Society’s Darwin Medal. John receives the medal “in recognition of his novel and convincing work on prebiotic chemistry, in particular his solution to the central problem of nucleoside synthesis”. The Darwin Medal is awarded biennially for “work of acknowledged […]
How cells adapt proteasome assembly under stress conditions
Research carried out by Anne Bertolotti’s group in the LMB’s Neurobiology Division has identified a novel protein, named Adc17, that acts as an inducible chaperone to help cells make more proteasome when needed. Cells and organisms constantly need to adapt to maintain protein homeostasis under adverse stress conditions in order to avoid cell death. Cells […]
Two LMB Scientists’ archives added to the Wellcome Library
The archive papers of two former LMB scientists, John Sulston and Alan Coulson, have been added to the Wellcome Library.
Worm neuron hack to probe the mysteries of our brains
Hijacking how neurons of nematode worms are wired is the first step in an approach that could revolutionise our understanding of brains and consciousness. Research by the LMB’s Bill Schafer and his team is highlighted in New Scientist. More…
Scientists map one of most important proteins in life and cancer
David Barford and his group, at the LMB and at the Institute of Cancer Research in London, have used cryo-EM to reveal the secondary structure of a vital protein in cell division: the human anaphase-promoting complex (APC/C). More…