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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > mRNA on the move – localisation can affect cell signalling and regulation

mRNA on the move – localisation can affect cell signalling and regulation

mRNA on the move – localisation can affect cell signalling and regulation

Published on 26 August, 2014

New research from Madan Babu’s group in the LMB’s Structural Studies Division, in collaboration with Toby Gibson from the European Molecular Biology Laboratory in Heidelberg, has shown that the targeted movement of mRNA molecules to allow proteins to be synthesised in specific locations has important implications in cell signalling and development. Proteins have many different […]

Journal allows authors to update their research

Published on 22 August, 2014

The open access journal eLife has launched a new type of article that will allow authors to report significant additions to their original research. LMB group leader, Sjors Scheres, becomes the first author to publish a research advance article, an update on his paper that reported an important step forward in electron cryo-microscopy. More…

The mother’s role in protecting the fetal genome from aldehyde damage is revealed.

Published on 22 August, 2014

Whilst a mother’s metabolism provides essential nutrients to enable embryonic development, both mother and embryo can also produce reactive metabolites that can damage DNA. Research undertaken by Nina Oberbeck in KJ Patel’s group, in the LMB’s PNAC Division, has uncovered how the embryo is protected from these genotoxins. Birth defects are common and are a […]

John Sutherland awarded the 2014 Royal Society Darwin Medal

Published on 5 August, 2014

John Sutherland, from the LMB’s Protein and Nucleic Acid Chemistry Division, has been awarded the Royal Society’s Darwin Medal. John receives the medal “in recognition of his novel and convincing work on prebiotic chemistry, in particular his solution to the central problem of nucleoside synthesis”. The Darwin Medal is awarded biennially for “work of acknowledged […]

How cells adapt proteasome assembly under stress conditions

Published on 4 August, 2014

Research carried out by Anne Bertolotti’s group in the LMB’s Neurobiology Division has identified a novel protein, named Adc17, that acts as an inducible chaperone to help cells make more proteasome when needed. Cells and organisms constantly need to adapt to maintain protein homeostasis under adverse stress conditions in order to avoid cell death.  Cells […]

Two LMB Scientists’ archives added to the Wellcome Library

Published on 28 July, 2014

The archive papers of two former LMB scientists, John Sulston and Alan Coulson, have been added to the Wellcome Library.

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